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产品信息
PA5-21790
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 105 and 336 of ACMSD (Uniprot ID#Q8TDX5)
偶联物
形式
Liquid
浓度
0.86 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.025% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_11155616
产品详细信息
Recommended positive controls: 293T, A431, H1299, HeLa, Molt-4, Raji, mouse brain.
Predicted reactivity: Mouse (91%), Rat (89%), Zebrafish (87%), Bovine (93%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.[supplied by OMIM, Oct 2004]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Picolinate carboxylase
基因别名: ACMSD
UniProt ID: (Human) Q8TDX5, (Mouse) Q8R519
Entrez Gene ID: (Human) 130013, (Mouse) 266645
