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Immunogen sequence: QLLEVPPQT QFDYTVTNLA GGPKPYSPYD SQYHETTLKG GMFAGQLTKV GMQQMFALGE RLRKNYVEDI PFLSPTFNPQ EVFIRSTNIF RNLESTRCLL AGLFQCQKEG PIIIHTDEAD SEVLYPNYQS CWSLRQRTRG RRQTASLQPG ISEDLKKVKD RMGIDSSDKV DFFILLDNVA AEQAHNLPSC PMLKRFARMI EQRAVDTSLY ILPKEDRESL QMAVGPFLHI LESNLLKAMD SATAPDKIRK LYLYAAHDVT FIPLLMTLGI FDHKWPPFAV DLTMELYQHL ESKEWFVQLY YHGKEQVPRG CPDGLCPLDM FLNAMSVYTL SPEKYHALCS QTQVMEVGNE E (79-429 aa encoded by BC034686)
Lysophosphatidic acid phosphatase type 6 (ACP6), also designated acid phosphatase-like protein 1 (ACPL1) or lysophosphatidic acid phosphatase (LPAP), is a 428 amino acid secreted protein that hydrolyzes lysophosphatidic acid to monoacylglycerol. ACP6 is highly expressed in kidney, heart, small intestine, muscle, liver, prostate, testis, ovary and exists as two isoforms as a result of alternative splicing events. The gene encoding ACP6 maps to human chromosome 1, the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene of human chromosome 1, which encodes lamin A. Stickler syndrome, Parkinsons, Gaucher disease, familial adenomatous polyposis and Usher syndrome are also associated with chromosome 1. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: 3.1.3.2; Acid phosphatase 6, lysophosphatidic; acid phosphatase like 1; Acid phosphatase-like protein 1; Lysophosphatidic acid phosphatase type 6; PACPL1
基因别名: 5730559A09Rik; ACP6; ACPL1; AU022842; LPAP; mPACPL1; PACPL1; UNQ205/PRO231
UniProt ID: (Human) Q9NPH0, (Mouse) Q8BP40
Entrez Gene ID: (Human) 51205, (Mouse) 66659