Proteintech

ACTN2 Monoclonal Antibody (1D5F9)

查看其他35个alpha Actinin 2抗体

抗体检测数据 (2)

ACTN2 Antibody in Western Blot (WB)

ACTN2 Antibody in Western Blot (WB)

图: 1 / 2

ACTN2 Antibody (68223-1-IG) in WB

Various lysates were subjected to SDS PAGE followed by western blot with 68223-1-Ig (ACTN2 antibody) at dilution of 1:50000 incubated at room temperature for 1.5 hours.

ACTN2 Antibody in Western Blot (WB)

ACTN2 Antibody in Western Blot (WB)

Product Image Gallery

ACTN2 Antibody in Western Blot (WB) — Various lysates were subjected to SDS PAGE followed by western blot with 68223-1-Ig (ACTN2 antibody) at dilution of 1:50000 incubated at room temperature for 1.5 hours.

ACTN2 Antibody in Western Blot (WB) — rat colon tissue were subjected to SDS PAGE followed by western blot with 68223-1-Ig (ACTN2 antibody) at dilution of 1:50000 incubated at room temperature for 1.5 hours.

产品信息

68223-1-IG

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:20,000-1:100,000

-

酶联免疫吸附实验 (ELISA)

Assay-dependent

-

产品规格

种属反应

Human, Mouse, Pig, Rabbit, Rat

宿主/亚型

Mouse / IgG2b

分类

Monoclonal

类型

Antibody

克隆号

1D5F9

抗原

Recombinant protein

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

纯化类型

Protein A

保存液

PBS with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

产品详细信息

Immunogen sequence: MNQIEPGVQY NYVYDEDEYM IQEEEWDRDL LLDPAWEKQQ RKTFTAWCNS HLRKAGTQIE NIEEDFRNGL KLMLLLEVIS GERLPKPDRG KMRFHKIANV NKALDYIASK GVKLVSIGAE EIVDGNVKMT LGMIWTIILR FAIQDISVEE TSAKEGLLLW CQRKTAPYRN VNIQNFHTSW KDGLGLCALI HRHRPDLIDY SKLNKDDPIG NINLAMEIAE KHLDIPKMLD AEDIVNTPKP DERAIMTYVS CFYHAFAGAE QAETAANRIC KVLAVNQENE RLMEEYERLA SELLEWIRRT I

靶标信息

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it i involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: actinin, alpha 2; alpha-actinin skeletal muscle; Alpha-actinin skeletal muscle isoform 2; Alpha-actinin-2; F-actin cross-linking protein

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基因别名: 1110008F24Rik; ACTN2; CMD1AA; CMH23

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UniProt ID: (Human) P35609, (Mouse) Q9JI91

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Entrez Gene ID: (Human) 88, (Rabbit) 100350274, (Pig) 100157406, (Mouse) 11472, (Rat) 291245

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Ras guanyl-nucleotide exchange factor activity integrin binding calcium ion binding protein binding phosphatidylinositol-4,5-bisphosphate binding cytoskeletal protein binding structural constituent of muscle protein domain specific binding LIM domain binding thyroid hormone receptor coactivator activity titin binding identical protein binding protein homodimerization activity ion channel binding protein dimerization activity actin filament binding FATZ binding titin Z domain binding actin binding ligand-dependent nuclear receptor transcription coactivator activity protein binding, bridging metal ion binding

参与通路

MAPK cascade platelet degranulation cell adhesion microspike assembly muscle filament sliding regulation of membrane potential regulation of apoptotic process negative regulation of potassium ion transport positive regulation of potassium ion transport positive regulation of GTPase activity sarcomere organization focal adhesion assembly protein homotetramerization actin filament uncapping cardiac muscle cell development phospholipase C-activating angiotensin-activated signaling pathway establishment of protein localization to plasma membrane negative regulation of potassium ion transmembrane transporter activity positive regulation of potassium ion transmembrane transporter activity regulation of nucleic acid-templated transcription negative regulation of protein localization to cell surface positive regulation of receptor activity positive regulation of endocytic recycling positive regulation of cation channel activity muscle contraction