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产品信息
MA5-37487
产品规格
种属反应
Mouse
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
179CT11.2.1
抗原
ACVR1B recombinant protein
偶联物
形式
Liquid
纯化类型
Protein G
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2897420
靶标信息
ACVR1B is a serine/threonine kinase involved in signal transduction and cellular communication. Several truncated ACVR1B isoforms have been reported to be exclusively expressed in human pituitary tumors. Mutations of ACVR1B have been observed in pancreatic adenocarcinomas. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. ACVR1B encodes activin A type IB receptor, composed of 11 exons. Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and a potential fourth variant contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Activin receptor type IB; Activin receptor type-1B; Activin receptor-like kinase 4; ACTR-IB; ACTRI; ACVR1A; ACVRLK2; ALK-4; ALK2; FOP; Serine/threonine-protein kinase receptor R2; SKR2; TSRI
基因别名: 6820432J04; ActR-IB; ActRIB; Acvr1b; Acvrlk4; Alk4; SKR2
UniProt ID: (Mouse) Q61271
Entrez Gene ID: (Mouse) 11479
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
transmembrane receptor protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
protein binding
ATP binding
kinase activity
activin receptor activity, type I
transferase activity
transferase activity, transferring phosphorus-containing groups
activin-activated receptor activity
growth factor binding
inhibin binding
SMAD binding
metal ion binding
activin binding
serine/threonine protein kinase receptor
G1/S transition of mitotic cell cycle
in utero embryonic development
hair follicle development
regulation of transcription, DNA-templated
protein phosphorylation
signal transduction
cell surface receptor signaling pathway
transmembrane receptor protein serine/threonine kinase signaling pathway
mesoderm development
embryo development
regulation of signal transduction
positive regulation of gene expression
negative regulation of gene expression
positive regulation of pathway-restricted SMAD protein phosphorylation
phosphorylation
peptidyl-threonine phosphorylation
signal transduction by protein phosphorylation
negative regulation of cell growth
activin receptor signaling pathway
positive regulation of activin receptor signaling pathway
intracellular signal transduction
nodal signaling pathway
positive regulation of erythrocyte differentiation
positive regulation of transcription from RNA polymerase II promoter
protein autophosphorylation
extrinsic apoptotic signaling pathway
positive regulation of trophoblast cell migration
