Invitrogen

ACVR2B Polyclonal Antibody

查看其他16个ACVR2B抗体

抗体检测数据 (2)

ACVR2B Antibody in Western Blot (WB)

ACVR2B Antibody in Western Blot (WB)

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ACVR2B Antibody (PA5-13888) in WB

Western blot analysis of ACVR2B in human pancreas tissue lysate. Samples were incubated with ACVR2B polyclonal antibody (Product # PA5-13888) using a dilution of 1:1,000 followed by goat anti-rabbit IgG H&L (HRP) at a dilution of 1:10,000. Lysate at 35 µg.

ACVR2B Antibody in Western Blot (WB)

ACVR2B Antibody in Western Blot (WB)

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ACVR2B Antibody in Western Blot (WB) — Western blot analysis of ACVR2B in human pancreas tissue lysate. Samples were incubated with ACVR2B polyclonal antibody (Product # PA5-13888) using a dilution of 1:1,000 followed by goat anti-rabbit IgG H&L (HRP) at a dilution of 1:10,000. Lysate at 35 µg.

ACVR2B Antibody in Western Blot (WB) — Western blot analysis of ACVR2B in Jurkat cell line lysates. Samples were incubated with ACVR2B polyclonal antibody (Product # PA5-13888). Lysates: 35 µg/lane. ACVR2B (arrow).

产品信息

PA5-13888

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000

-

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

KLH conjugated synthetic peptide selected between aa 1 and 30 of human ACVR2B

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.8 mg/mL

纯化类型

Ammonium sulfate precipitation, Size-exclusion - Dialysis

保存液

PBS, pH 7.4

内含物

0.09% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2222465

靶标信息

ACVR2B is a type II member of the TGF-beta family of receptor ser/thr kinases and is involved in the activin and myostatin signaling pathway. Activins and inhibins are members of the TGF-beta superfamily due to amino acid homology with respect to the conservation of 7 of the 9 cysteine residues common to all TGF-beta forms. To date, seven type I and five type II activin receptors have been cloned from mammals, including activin receptor IA, activin receptor IIA, activin receptor IB, and activin receptor IIB. In addition, two splice variants of activin receptor IIA and five splice variants of activin receptor IIB have been reported.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: activin A receptor type IIB; activin A receptor, type IIB; Activin receptor type IIB; Activin receptor type-2B; ACTR-IIB; MGC116908

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基因别名: ActR-IIB; ACTRIIB; ACVR2B; HTX4

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UniProt ID: (Human) Q13705

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Entrez Gene ID: (Human) 93

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protein serine/threonine kinase activity receptor signaling protein serine/threonine kinase activity protein serine/threonine/tyrosine kinase activity protein binding ATP binding activin receptor activity, type II growth factor binding inhibin binding metal ion binding activin binding serine/threonine protein kinase receptor

参与通路

negative regulation of transcription from RNA polymerase II promoter gastrulation with mouth forming second kidney development lymphangiogenesis blood vessel remodeling regulation of transcription, DNA-templated signal transduction transmembrane receptor protein serine/threonine kinase signaling pathway determination of left/right symmetry mesoderm development heart development response to glucose post-embryonic development anterior/posterior pattern specification signal transduction by protein phosphorylation insulin secretion lung development positive regulation of bone mineralization BMP signaling pathway pancreas development activation of protein kinase activity activin receptor signaling pathway positive regulation of activin receptor signaling pathway organ growth odontogenesis of dentin-containing tooth positive regulation of osteoblast differentiation embryonic foregut morphogenesis skeletal system morphogenesis palate development lymphatic endothelial cell differentiation artery development venous blood vessel development retina vasculature development in camera-type eye