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产品信息
PAC6-FITC
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to N-terminal amino acids 13-27 of rat Particulate Adenylyl Cyclase 6 protein. Peptide was covalently modified and conjugated to KLH.Sequence:DERKTAWGERNGQKR
偶联物
激发/发射光谱
498/517 nm
查看光谱
形式
Liquid
浓度
0.5-1.5 mg/mL
纯化类型
Affinity chromatography
保存液
proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, store in dark
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
This gene encodes a member of the adenylyl cyclase family of proteins, which are required for the synthesis of cyclic AMP. All members of this family have an intracellular N-terminus, a tandem repeat of six transmembrane domains separated by a cytoplasmic loop, and a C-terminal cytoplasmic domain. The two cytoplasmic regions bind ATP and form the catalytic core of the protein. Adenylyl cyclases are important effectors of transmembrane signaling pathways and are regulated by the activity of G protein coupled receptor signaling. This protein belongs to a small subclass of adenylyl cyclase proteins that are functionally related and are inhibited by protein kinase A, calcium ions and nitric oxide. A mutation in this gene is associated with arthrogryposis multiplex congenita.
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生物信息学
蛋白别名: AC6; ACVI; Adenylate cyclase type 6; Adenylate cyclase type VI; Adenylyl cyclase 6; ATP pyrophosphate-lyase 6; Ca(2+)-inhibitable adenylyl cyclase; DKFZp779F075
基因别名: AC6; ACVI; ADCY6; ADCYB; KIAA0422; LCCS8; mKIAA0422
UniProt ID: (Human) O43306, (Rat) Q03343
Entrez Gene ID: (Human) 112, (Rat) 25289, (Mouse) 11512
cAMP biosynthetic process
dopamine receptor signaling pathway
negative regulation of neuron projection development
intracellular signal transduction
cellular response to prostaglandin E stimulus
cellular response to catecholamine stimulus
maintenance of protein location in plasma membrane
cyclic nucleotide biosynthetic process
renal water homeostasis
adenylate cyclase-activating G-protein coupled receptor signaling pathway
activation of adenylate cyclase activity
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
cAMP-mediated signaling
activation of protein kinase A activity
negative regulation of urine volume
regulation of vasodilation
cellular response to glucagon stimulus
cellular response to vasopressin
cellular response to forskolin
