Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
图: 1 / 4
AGTR1 Antibody (MA5-42535) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of of Angiotensin II Type 1 Receptor in PC-12 cells (green). Formalin fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 10 minutes at room temperature and blocked with 1% Blocker BSA for 15 minutes at room temperature. Cells were probed with AGTR1 Monoclonal Antibody (Product # MA5-42535) at a dilution of 1:50 for 1 hour at room temperature, washed with PBS. Alexa Fluor 488 Goat anti-Mouse IgG was used as the secondary antibody at 1:1,000 dilution. The nuclear counter stain is ... View More
产品信息
MA5-42535
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
11B3
抗原
Synthetic peptide within human Angiotensin II Type 1 Receptor aa 300-350
偶联物
形式
Liquid
浓度
2 mg/mL
纯化类型
Protein G
保存液
TBS, pH 7.4, with 50% glycerol, 0.2% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2911676
产品详细信息
Positive Control: PC-12 cell lysate, A549 cell lysate, HepG2 cell lysate, Hela cell lysate, PC-12, 293T, A549.
Subcellular Location: Cell membrane, Membrane.
靶标信息
AGTR1 is known as Angiotensin II Type 1 Receptor. Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. And it acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. Moreover, this gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: angiotensin II receptor, type 1; Angiotensin II type-1 receptor; Angiotensin II type-1 receptor A; angiotensin II type-1A receptor; angiotensin receptor 1; angiotensin receptor 1a; AT1 receptor; AT1 receptor A; AT1AR; AT1BR; Type-1 angiotensin II receptor; Type-1 angiotensin II receptor A; type-1A angiotensin II receptor; type-1B angiotensin II receptor; vascular type-1 angiotensin II receptor
基因别名: 1810074K20Rik; AG2S; Agtr-1a; AGTR1; AGTR1A; AGTR1B; AI551199; Angtr-1a; AT1; AT1A; AT1AR; AT1B; AT1BR; AT1R; AT2R1; AT2R1A; AT2R1B; HAT1R
UniProt ID: (Human) P30556, (Rat) P25095, (Mouse) P29754
Entrez Gene ID: (Human) 185, (Rat) 24180, (Mouse) 11607
angiotensin type I receptor activity
angiotensin type II receptor activity
protein binding
bradykinin receptor binding
protein heterodimerization activity
G-protein alpha-subunit binding
peptide hormone binding
protein kinase binding
D1 dopamine receptor binding
protein self-association
signal transducer activity
G-protein coupled receptor activity
G-protein coupled receptor
regulation of cell growth
kidney development
renin-angiotensin regulation of aldosterone production
regulation of blood vessel size by renin-angiotensin
regulation of systemic arterial blood pressure by renin-angiotensin
G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
Rho protein signal transduction
positive regulation of macrophage derived foam cell differentiation
positive regulation of cholesterol esterification
regulation of vasoconstriction
calcium-mediated signaling
positive regulation of cellular protein metabolic process
positive regulation of phospholipase A2 activity
positive regulation of NAD(P)H oxidase activity
low-density lipoprotein particle remodeling
regulation of renal sodium excretion
angiotensin-activated signaling pathway
regulation of cell proliferation
regulation of vasodilation
regulation of inflammatory response
positive regulation of inflammatory response
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
cell chemotaxis
phospholipase C-activating angiotensin-activated signaling pathway
positive regulation of reactive oxygen species metabolic process
blood vessel development
positive regulation of receptor recycling
regulation of systemic arterial blood pressure by circulatory renin-angiotensin
renin secretion into blood stream
regulation of renal output by angiotensin
brain renin-angiotensin system
regulation of pH
inflammatory response
heart development
aging
regulation of blood pressure
positive regulation of cell proliferation
positive regulation of superoxide anion generation
regulation of smooth muscle cell apoptotic process
negative regulation of smooth muscle cell apoptotic process
vasoconstriction
dopamine biosynthetic process
drinking behavior
activation of Janus kinase activity
negative regulation of neuron apoptotic process
response to estrogen
positive regulation of blood pressure
positive regulation of cytokine secretion
cellular response to dexamethasone stimulus
positive regulation of branching involved in ureteric bud morphogenesis
signal transduction
