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产品信息
22517-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Not Applicable
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
AIRE Fusion Protein Ag18249 (96-348 aa encoded by BC137270)
偶联物
形式
Liquid
浓度
0.27 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: QKNEDECAV CRDGGELICC DGCPRAFHLA CLSPPLREIP SGTWRCSSCL QATVQEVQPR AEEPRPQEPP VETPLPPGLR SAGEEVRGPP GEPLAGMDTT LVYKHLPAPP SAAPLPGLDS SALHPLLCVG PEGQQNLAPG ARCGVCGDGT DVLRCTHCAA AFHWRCHFPA GTSRPGTGLR CRSCSGDVTP APVEGVLAPS PARLAPGPAK DDTASHEPAL HRDDLESLLS EHTFDGILQW AIQSMARPAA PFPS (96-348 aa encoded by BC137270)
靶标信息
AIRE is a transcriptional regulator protein that binds to DNA as a dimer and tetramer, but not as a monomer, and may be involved in the regulation of gene expression. A nuclear protein, AIRE is a 545 amino acid protein with an HSR domain, two PHD type zinc fingers, and a SAND domain, and may be present in soluble high-molecular-weight complexes. It may form homodimer, homotetramer and also nuclear bodies and interacts with the transcriptional coactivator CBP and CREBBP. Three isoforms of AIRE are reported and one of them is predicted to be a candidate for nuclear-mediated decay (NMD). AIRE is involved in immune regulation and is known to mediate E3 ubiquitin ligase activity. Defects in AIRE are responsible for the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: AIRE protein; APECED protein; APECED protein homolog; Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein; Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog; Autoimmune regulator; autoimmune regulator AIRE1a; OTTHUMP00000109529
基因别名: AIRE; AIRE1; APECED; APS1; APSI; PGA1
UniProt ID: (Human) O43918, (Mouse) Q9Z0E3
Entrez Gene ID: (Human) 326, (Mouse) 11634
RNA polymerase II regulatory region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
chromatin binding
transcription cofactor activity
protein binding
zinc ion binding
histone binding
identical protein binding
transcription regulatory region DNA binding
translation regulator activity
DNA binding
metal ion binding
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
regulation of translation
immune response
humoral immune response
negative thymic T cell selection
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
