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产品信息
PA5-18525
产品规格
种属反应
Human,
Pig
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide sequence (KDVDLSQPRKGRKP) corresponding to the internal amino acids of AIRE
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_10987323
产品详细信息
This antibody is predicted to react with bovine, canine and rat based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 32,000.
靶标信息
AIRE is a transcriptional regulator protein that binds to DNA as a dimer and tetramer, but not as a monomer, and may be involved in the regulation of gene expression. A nuclear protein, AIRE is a 545 amino acid protein with an HSR domain, two PHD type zinc fingers, and a SAND domain, and may be present in soluble high-molecular-weight complexes. It may form homodimer, homotetramer and also nuclear bodies and interacts with the transcriptional coactivator CBP and CREBBP. Three isoforms of AIRE are reported and one of them is predicted to be a candidate for nuclear-mediated decay (NMD). AIRE is involved in immune regulation and is known to mediate E3 ubiquitin ligase activity. Defects in AIRE are responsible for the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).
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生物信息学
蛋白别名: AIRE protein; APECED protein; Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein; Autoimmune regulator; OTTHUMP00000109529
基因别名: AIRE; AIRE1; APECED; APS1; APSI; PGA1
UniProt ID: (Human) O43918
Entrez Gene ID: (Human) 326, (Pig) 100621659
RNA polymerase II regulatory region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
chromatin binding
transcription cofactor activity
protein binding
zinc ion binding
histone binding
identical protein binding
transcription regulatory region DNA binding
translation regulator activity
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
regulation of translation
immune response
humoral immune response
negative thymic T cell selection
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
