Search Thermo Fisher Scientific
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MSSSKKSKEK EKEKDKIKEK EKDSKDKEKD KKTVNGHTFS SIPVVGPISC SQCMKPFTNK DAYTCANCSA FVHKGCRESL ASCAKVKMKQ PKGSLQAHDT SSLPTVIMRN KPSQPKERPR SAVLLVDETA TTPIFANRRS QQSVSLSKSV SIQNITGVGN DENMSNTWKF LSHSTDSLNK ISKVNESTES LTDEGVGTDM NEGQLLGDFE IESKQLEAES WSRIIDSKFL KQQKKDVVKR QEVIYELMQT EFHHVRTLKI MSGVYSQGMM ADLLFEQQMV EKLFPCLDEL ISIHSQFFQR ILERKKESLV DKSEKNFLIK RIGDVLVNQF SGENAERLKK TYGKFCGQHN QSVNYFKDLY AKDKRFQAFV KKKMSSSVVR RLGIPECILL VTQRITKYPV LFQRILQCTK DNEVEQEDLA QSLSLVKDVI GAVDSKVASY EKKVRLNEIY TKTDSKSIMR MKSGQMFAKE DLKRKKLVRD GSVFLKNAAG RLKEVQAVLL TDILVFLQEK DQKYIFASLD QKSTVISLKK LIVREVAHEE KGLFLISMGM TDPEMVEVHA SSKEERNSWI QIIQDTINTL NRDEDEGIPS ENEEEKKMLD TRARELKEQL HQKDQKILLL LEEKEMIFRD MAECSTPLPE DCSPTHSPRV LFRSNTEEAL KGGPLMKSAI NEVEILQGLV SGNLGGTLGP TVSSPIEQDV VGPVSLPRRA ETFGGFDSHQ MNASKGGEKE EGDDGQDLRR TESDSGLKKG GNANLVFMLK RNSEQVVQSV VHLYELLSAL QGVVLQQDSY IEDQKLVLSE RALTRSLSRP SSLIEQEKQR SLEKQRQDLA NLQKQQAQYL EEKRRREREW EARERELRER EALLAQREEE VQQGQQDLEK EREELQQKKG TYQYDLERLR AAQKQLEREQ EQLRREAERL SQRQTERDLC QVSHPHTKLM RIPSFFPSPE EPPSPSAPSI AKSGSLDSEL SVSPKRNSIS RTHKDKGPFH ILSSTSQTNK GPEGQSQAPA STSASTRLFG LTKPKEKKEK KKKNKTSRSQ PGDGPASEVS AEGEEIFC
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms containing c-terminal dbl oncogene homology (DH) and pleckstrin homology (PH) domains. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway, function as protein kinase A-anchoring proteins and, in addition, enhance ligand-dependent activity of estrogen receptors alpha and beta.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: A kinase (PRKA) anchor protein 13; A-kinase anchor protein 13; A-kinase anchoring protein; AKAP-13; AKAP-Lbc; Breast cancer nuclear receptor-binding auxiliary protein; Guanine nucleotide exchange factor Lbc; Human thyroid-anchoring protein 31; LBC oncogene; Lymphoid blast crisis oncogene; Non-oncogenic Rho GTPase-specific GTP exchange factor; p47; PRKA13; Protein kinase A-anchoring protein 13
基因别名: AKAP-13; AKAP-Lbc; AKAP13; ARHGEF13; BRX; c-lbc; HA-3; HT31; LBC; p47; PRKA13; PROTO-LB; PROTO-LBC
UniProt ID: (Human) Q12802
Entrez Gene ID: (Human) 11214