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Immunogen sequence: MATFVELST KAKMPIVGLG TWKSPLGKVK EAVKVAIDAG YRHIDCAYVY QNEHEVGEAI QEKIQEKAVK REDLFIVSKL WPTFFERPLV RKAFEKTLKD LKLSYLDVYL IHWPQGFKSG DDLFPKDDKG NAIGGKATFL DAWEAMEELV DEGLVKALGV SNFSHFQIEK LLNKPGLKYK PVTNQVECHP YLTQEKLIQY CHSKGITVTA YSPLGSPDRP WAKPEDPSLL EDPKIKEIAA KHKKTAAQVL IRFHIQRNVI VIPKSVTPAR IVENIQVFDF KLSDEEMATI LSFNRNWRAC NVLQSSHLED YPFDAEY (1-316 aa encoded by BC008837)
AKR1B10, a 316aa protein, catalyzes efficient reduction ofaliphatic and aromatic aldehydes. It the first cytosolic NADP (H)-dependent retinal reductase described in humans and is characterized by the presence of a novel NADP binding motif. Due to its ability to convert glucose to sorbitol, AKR1B10 may have a role in development of secondary diabetic complications.It is abundantly expressed in adrenal gland, small intestine and colon, with lower levels in liver, thymus, prostate, testis, and skeletal muscle and its levels are up regulated in certain cancers such as hepatocellular carcinoma.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Aldo-keto reductase family 1 member B10; aldo-keto reductase family 1, member B10; aldo-keto reductase family 1, member B10 (aldose reductase); aldo-keto reductase family 1, member B11 (aldose reductase-like); Aldose reductase-like; aldose reductase-like 1; aldose reductase-like peptide; Aldose reductase-related protein; ARL-1; ARP; hARP; MGC14103; SI reductase; Small intestine reductase
基因别名: 2310005E10Rik; AKR1B10; AKR1B11; AKR1B12; Akr1b16; ALDRLn; ARL-1; ARL1; HIS; HSI
UniProt ID: (Human) O60218
Entrez Gene ID: (Human) 57016, (Rat) 296972, (Mouse) 67861
分子生物学功能:
oxidoreductase
reductase
metabolite interconversion enzyme