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ALDH1A1 Antibody (PA5-140974) in ICC/IF
Immunocytochemistry analysis of Aldh1A1 in HepG2 cells (green). Samples were incubated in Aldh1A1 Polyclonal antibody (Product # PA5-140974). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilized with 0.25% Triton X100/PBS.
产品信息
PA5-140974
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant full length protein of human Aldh1A1.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4, with 0.2% BSA, 50% glycerol
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2932426
靶标信息
ALDH1A1 belongs to the aldehyde dehydrogenases family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of the mitochondrial isozyme.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 3-deoxyglucosone dehydrogenase; acetaldehyde dehydrogenase 1; alcohol dehydrogenase family 1, subfamily A1; alcohol dehydrogenase family 1, subfamily A2; aldehyde dehydrogenase 1 family, member A1; Aldehyde dehydrogenase 1 soluble; aldehyde dehydrogenase 1, liver cytosolic (class 1); aldehyde dehydrogenase 1, soluble; aldehyde dehydrogenase 1, subfamily A1; Aldehyde dehydrogenase 1A1; aldehyde dehydrogenase 2; Aldehyde dehydrogenase family 1 member A1; aldehyde dehydrogenase family 1, member A1; aldehyde dehydrogenase family 1, subfamily A1; Aldehyde dehydrogenase, cytosolic; aldehyde dehydrogenase, liver cytosolic; ALDH class 1; ALDH-E1; ALHDII; epididymis luminal protein 12; epididymis luminal protein 9; epididymis secretory sperm binding protein Li 53e; epididymis secretory sperm binding protein Li53e; MGC2318; RALDH 1; ralDH1; Retinal dehydrogenase 1; retinaldehyde dehydrogenase 1
基因别名: Ahd-2; Ahd2; ALDC; Aldh; ALDH-E1; ALDH1; ALDH11; ALDH1A1; Aldh1a2; Aldh2; E1; HEL-9; HEL-S-53e; HEL12; PUMB1; RALDH1
UniProt ID: (Human) P00352, (Mouse) P24549, (Rat) P51647
Entrez Gene ID: (Human) 216, (Mouse) 11668, (Rat) 24188
retinal dehydrogenase activity
aldehyde dehydrogenase (NAD) activity
GTPase activator activity
androgen binding
benzaldehyde dehydrogenase (NAD+) activity
3-chloroallyl aldehyde dehydrogenase activity
oxidoreductase activity
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
identical protein binding
dehydrogenase
oxidoreductase
metabolite interconversion enzyme
ethanol oxidation
cellular aldehyde metabolic process
retinol metabolic process
positive regulation of GTPase activity
fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate
optic cup morphogenesis involved in camera-type eye development
retinoic acid biosynthetic process
response to oxidative stress
metabolic process
response to drug
retinoic acid metabolic process
9-cis-retinoic acid biosynthetic process
9-cis-retinoic acid metabolic process
positive regulation of apoptotic process
response to ethanol
embryonic eye morphogenesis
protein homotetramerization
oxidation-reduction process
kidney development
liver development
midgut development
response to organic cyclic compound
response to estradiol
response to retinoic acid
estrous cycle
