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OriGene
ALDH3A2 Monoclonal Antibody (OTI1H4), TrueMAB™
高级验证
This Antibody was verified by Knockout to ensure that the antibody binds to the antigen stated.
图: 1 / 3
ALDH3A2 Antibody (CF503197) in WB
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ALDH3A2 (RC200648, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-ALDH. Positive lysates LY422196 (100 µg) and LC422196 (20 µg) can be purchased separately from OriGene.
产品信息
CF503197
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
OTI1H4
抗原
Full length human recombinant protein of human ALDH3A2 produced in HEK293T cell.
偶联物
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 8% trehalose
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
靶标信息
Aldh3A2 is a member of the aldehyde dehydrogenase superfamily, a group of NAD(P)(+)-dependent enzymes that catalyze the oxidation of a wide spectrum of aliphatic and aromatic aldehydes. Aldehyde dehydrogenase enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. Aldh3A2 catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Mutations in the Aldh3A2 gene cause Sjogren-Larrson syndrome, an inherited neurocutaneous disorder. Patients with this disorder display ichthyosis, mental retardation and spastic diplegia. The pathogenesis of the cutaneous and neurological symptoms is thought to result from abnormal lipid accumulation in the membranes of skin and brain, the formation of aldehyde Schiff base adducts with amine-containing lipids or proteins, or defective eicosanoid metabolism.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Aldehyde dehydrogenase 10; aldehyde dehydrogenase 3 family, member A2; Aldehyde dehydrogenase family 3 member A2; DKFZp686E23276; Fatty aldehyde dehydrogenase; FLJ20851; Microsomal aldehyde dehydrogenase
基因别名: ALDH10; ALDH3A2; FALDH; SLS
UniProt ID: (Human) P51648
Entrez Gene ID: (Human) 224
response to reactive oxygen species
fatty acid alpha-oxidation
cellular aldehyde metabolic process
central nervous system development
peripheral nervous system development
epidermis development
sphingolipid biosynthetic process
phytol metabolic process
formaldehyde metabolic process
oxidation-reduction process
