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4D11 reacts with CRASH, a 308 AA glycoprotein, sharing 32% homology with human asparaginase and identical to Asparaginase-Like Protein (ALP) found in rat sperm. CRASH is found in a variety of tumors but only occasionally in normal tissues. Especially ovarian cancers are highly positive. CRASH is further found in brain tumors, some colonic cancers, some lung cancers, some prostate cancers, uterine cancers, some breast cancers and some thyroid cancers. It was not found in serum. In Western blot 3 bands are demonstrated of 45 kDa, 28 kDa and 15 kDa.
ALP is found in a variety of tumors but only occasionally in normal tissues. Ovarian cancers are highly positive. ALP is further found in brain tumors, some colonic cancers, some lung cancers, some prostate cancers, uterine cancers, some breast cancers and some thyroid cancers. It was not found in serum.
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蛋白别名: asparaginase-like 1 protein; Asparaginase-like protein 1; Beta-aspartyl-peptidase; FLJ22316; Isoaspartyl dipeptidase; Isoaspartyl peptidase/L-asparaginase; L-asparaginase; L-asparagine amidohydrolase; testis secretory sperm-binding protein Li 242mP
基因别名: ALP; ALP1; ASRGL1; CRASH
UniProt ID: (Human) Q7L266
Entrez Gene ID: (Human) 80150
分子生物学功能:
protease