Invitrogen

AMOT Polyclonal Antibody

高级验证

This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.

查看其他19个AMOT抗体

说明书

实验方案

技术支持

说明书

实验方案

技术支持

抗体检测数据 (2)
高级验证 (1)

AMOT Antibody in Immunohistochemistry (IHC)

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AMOT Antibody (PA5-64322) in IHC

Immunohistochemical staining of AMOT in human placenta and pancreas tissues using AMOT Polyclonal Antibody (Product # PA5-64322). Corresponding AMOT RNA-seq data are presented for the same tissues.

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AMOT Antibody — Relative expression in different tissues in IHC: Detection of differential expression levels of AMOT demonstrates antibody specificity. Immunohistochemical analysis of AMOT using anti-AMOT Polyclonal Antibody (Product # PA5-64322), shows significant staining of AMOT in human placenta and shows minimal or weak staining in human pancreas tissues. The relative expression levels of AMOT within each tissue is shown using RNA-Seq. {RE}

产品信息

PA5-64322

应用

建议稀释比

已发表文章

免疫组化 (IHC)

1:500-1:1,000

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to Human AMOT. Recombinant protein control fragment (Product #RP-103986).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.2 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2637914

产品详细信息

Immunogen sequence: LSERLMQMSL ATSGVKAHPP VTSAPLSPPQ PNDLYKNPTS SSEFYKAQGP LPNQHSLKGM EHRG

Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 95%.

靶标信息

AMOT (Angiomotin) belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. AMOT plays a central role in tight junction maintenance via the complex formed with ARHGAP17 - which acts by regulating the uptake of polarity proteins at tight junctions. AMOT is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels.

仅用于科研。不用于诊断过程。未经明确授权不得转售。