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This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
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Recommended positive controls: mouse liver.
Predicted reactivity: Mouse (99%), Rat (98%), Zebrafish (88%), Xenopus laevis (80%), Pig (100%), Chicken (92%), Rhesus Monkey (100%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: 5'-AMP-activated protein kinase subunit gamma-1; 5'-AMP-activated protein kinase, gamma-1 subunit; ampk gamma; AMPK gamma-1 chain; AMPK gamma1; AMPK subunit gamma-1; AMPKg; protein kinase, AMP-activated, gamma 1 non-catalytic subunit
基因别名: AA571379; AMPKG; BB036179; Prkaac; PRKAG1
UniProt ID: (Human) P54619, (Mouse) O54950
Entrez Gene ID: (Human) 5571, (Mouse) 19082
分子生物学功能:
kinase modulator