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Immunogen sequence: EAGMLEKLE FEDEAVEDSE SGVYMRFMRS HKCYDIVPTS SKLVVFDTTL QVKKAFFALV ANGVRAAPLW ESKKQSFVGM LTITDFINIL HRYYKSPMVQ IYELEEHKIE TWRELYLQET FKPLVNISPD ASLFDAVYSL IKNKIHRLPV IDPISGNALY ILTHKRILKF LQLFMSDMPK PAFMKQNLDE LGIGTYHNIA FIHPDTPIIK ALNIFVERRI SALPVVDESG KVVDIYSKFD VINLAAEKTY NNLDITVTQA LQHRSQYFEG VVKCNKLEIL ETIVDRIVRA EVHRLVVVNE ADSIVGIISL SDILQALILT PAGAKQKETE TE (11-341 aa encoded by BC020540)
AMP-activated protein kinase (AMPK) is a heterotrimeric protein composed of a catalytic alpha subunit, a noncatalytic beta subunit, and a noncatalytic regulatory gamma subunit. Various forms of each of these subunits exist, encoded by different genes. AMPK is an important energy-sensing enzyme that monitors cellular energy status and functions by inactivating key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This gene is a member of the AMPK gamma subunit family and encodes a protein with four cystathionine beta-synthase domains. Mutations in this gene have been associated with ventricular pre-excitation (Wolff-Parkinson-White syndrome), progressive conduction system disease and cardiac hypertrophy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: 5'-AMP-activated protein kinase subunit gamma-2; 5-AMP-activated protein kinase, gamma-2 subunit; ampk gamma; AMPK gamma-2 chain; AMPK gamma2; AMPK subunit gamma-2; H91620p; OTTHUMP00000211956; protein kinase, AMP-activated, gamma 2 non-catalytic subunit
基因别名: 2410051C13Rik; AAKG; AAKG2; AI854673; CMH6; H91620p; PRKAG2; WPWS
UniProt ID: (Human) Q9UGJ0, (Mouse) Q91WG5
Entrez Gene ID: (Human) 51422, (Mouse) 108099
分子生物学功能:
kinase modulator