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This gene encodes a member of a family of secreted proteins that function in angiogenesis. The encoded protein, which is expressed predominantly in the liver, is further processed into an N-terminal coiled-coil domain-containing chain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metabolism, while the C-terminal chain may be involved in angiogenesis. Mutations in this gene cause familial hypobetalipoproteinemia type 2.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: ANG-5; angiopoietin 5; Angiopoietin-5; angiopoietin-like 3; Angiopoietin-like protein 3; Angiopoietin-related protein 3; hypolipidemia
基因别名: ANG-5; ANGPT5; ANGPTL3; ANL3; FHBL2; hypl; UNQ153/PRO179
UniProt ID: (Human) Q9Y5C1, (Mouse) Q9R182
Entrez Gene ID: (Human) 27329, (Mouse) 30924, (Rat) 502970
分子生物学功能:
intercellular signal molecule