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产品信息
PA5-30189
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein fragment corresponding to a region within amino acids 232 and 423 of Human AP2 beta
偶联物
形式
Liquid
浓度
0.95 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 1% BSA, 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2547663
产品详细信息
Recommended positive controls: MCF-7, rat brain.
Predicted reactivity: Mouse (100%), Rat (100%), Zebrafish (94%), Xenopus laevis (99%), Dog (100%), Pig (99%), Chicken (99%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
This gene encodes a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members differ in their expression patterns and binding affinity for different promoters. This protein functions as both a transcriptional activator and repressor. Mutations in this gene result in autosomal dominant Char syndrome, suggesting that this gene functions in the differentiation of neural crest cell derivatives.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: activating enhancer binding protein 2 beta; Activating enhancer-binding protein 2-beta; AP2-beta; transcription factor AP-2 beta (activating enhancer binding protein 2 beta); Transcription factor AP-2-beta
基因别名: AP-2B; AP2-B; Tcfap2b; TFAP2B
UniProt ID: (Human) Q92481
Entrez Gene ID: (Human) 7021, (Rat) 301285
RNA polymerase II core promoter sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II core promoter sequence-specific
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II transcription coactivator activity
RNA polymerase II transcription corepressor activity
enhancer sequence-specific DNA binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
transcription corepressor activity
protein binding
protein homodimerization activity
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
sequence-specific DNA binding
protein heterodimerization activity
protein dimerization activity
RNA polymerase II regulatory region sequence-specific DNA binding
general transcription factor
negative regulation of transcription from RNA polymerase II promoter
kidney development
renal water homeostasis
glucose metabolic process
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
apoptotic process
positive regulation of cell proliferation
negative regulation of cell proliferation
response to lithium ion
retina layer formation
magnesium ion homeostasis
regulation of BMP signaling pathway
forelimb morphogenesis
hindlimb morphogenesis
positive regulation of urine volume
aorta morphogenesis
response to drug
glucose homeostasis
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of neuron apoptotic process
positive regulation of neuron apoptotic process
skin development
fat cell differentiation
regulation of cell differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
sympathetic nervous system development
regulation of insulin secretion
phosphate ion homeostasis
calcium ion homeostasis
potassium ion homeostasis
sodium ion homeostasis
distal tubule development
collecting duct development
metanephric nephron development
ductus arteriosus closure
cellular ammonia homeostasis
cellular creatinine homeostasis
cellular urea homeostasis
regulation of transcription from RNA polymerase II promoter
regulation of cell proliferation
anatomical structure development
