Search Thermo Fisher Scientific
Immunogen sequence: DPSVRNVEV PEWTKCSNRE KRKEKEKPFY SDSEGESGPT ESADSDPESE SESDSKSSSE SGSGESSSES DNEDQDEDEE KGRGSESEQS EEDGKRKTKK KVPERKGEAS SSDEGSDSSS SSSESEMTSE SEEEQLEPAS WSRKTPPSSK SAPATKEISL LDLEDFTPPS VQPVSPPAIV STSLAADLEG LTLTDSTLVP SLLSPVSGVG RQELLHRVAG EGLAVDYTFS RQPFSGDPHM VSVHIHFSNS SDTPIKGLHV GTPKLPAGIS IQEFPEIESL APGESATAVM GINFCDSTQA ANFQLCTQTR QFYVSIQPPV GELMAPVFMS ENEFKKEQGK LMGMNEITEK LMLPDTCRSD HIVVQKVTAT ANLGRVPCGT SDEYRFAGRT LTGGSLVLLT LDARPAGAAQ LTVNSEKMVI GTMLVKDVIQ ALTQ (650-1082 aa encoded by BC093739)
The AP3 complex is a heterotetramer composed of two large adaptins (AP3D1, AP3B1 or AP3B2), a medium adaptin (AP3M1 or AP3M2) and a small adaptin (APS1 or AP3S2). The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Unlike the homologous AP3B1, AP3B2-containing AP3 complexes are preferentially targeted to neuronal processes, and mice deficient in AP3B2 displayed compromised synaptic zinc stores.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: adapter-related protein complex 3 subunit beta-2; adaptor protein complex AP-3 beta-2 subunit; Adaptor protein complex AP-3 subunit beta-2; adaptor related protein complex 3, beta 2 subunit; Adaptor-related protein complex 3 subunit beta-2; adaptor-related protein complex 3, beta 2 subunit; adaptor-related protein complex AP-3, beta 2 subunit; AP-3 complex beta-2 subunit; AP-3 complex subunit beta-2; ap3; Beta-3B-adaptin; beta3B-adaptin; Clathrin a; Clathrin assembly protein complex 3 beta-2 large chain; Neuron-specific vesicle coat protein beta-NAP; Neuronal adaptin-like protein, beta-subunit
基因别名: [b]-NAP; AI549966; AP3B2; AU042881; beta-NAP; beta3B; NAPTB
UniProt ID: (Human) Q13367, (Mouse) Q9JME5
Entrez Gene ID: (Human) 8120, (Mouse) 11775, (Rat) 308777
分子生物学功能:
membrane traffic protein