Invitrogen

APAF1 Polyclonal Antibody

高级验证

This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.

查看其他16个APAF1抗体

说明书

实验方案

技术支持

说明书

实验方案

技术支持

高级验证 (1)

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APAF1 Antibody (PA5-83190)

Relative expression in different tissues in IHC: Detection of differential expression levels of APAF1 demonstrates antibody specificity. Immunohistochemical analysis of APAF1 using anti-APAF1 Polyclonal Antibody (Product #PA5-83190), shows significant staining of APAF1 in lymph node and shows minimal or weak staining in pancreas tissues. The relative expression levels of APAF1 within each tissue is shown u... View More

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APAF1 Antibody — Relative expression in different tissues in IHC: Detection of differential expression levels of APAF1 demonstrates antibody specificity. Immunohistochemical analysis of APAF1 using anti-APAF1 Polyclonal Antibody (Product #PA5-83190), shows significant staining of APAF1 in lymph node and shows minimal or weak staining in pancreas tissues. The relative expression levels of APAF1 within each tissue is shown using RNA-Seq. {RE}

产品信息

PA5-83190

应用

建议稀释比

已发表文章

免疫组化 (IHC)

1:20-1:50

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to Human APAF1. Recombinant protein control fragment (Product #RP-95285).

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.05 mg/mL

纯化类型

Anitgen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2790346

产品详细信息

Immunogen sequence: PLVVSLIGAL LRDFPNRWEY YLKQLQNKQF KRIRKSSSYD YEALDEAMSI SVEMLREDIK DYYTDLSILQ KDVKVPTKVL CILWDMETEE VEDILQEFVN KSLLFCDR

靶标信息

APAF1 gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.

仅用于科研。不用于诊断过程。未经明确授权不得转售。