Invitrogen

APBB2 Polyclonal Antibody

高级验证

This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.

1个已发表图片

1 篇参考文献

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说明书

实验方案

技术支持

说明书

实验方案

技术支持

APBB2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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APBB2 Antibody (PA5-54816) in IHC (P)

Immunohistochemical analysis of APBB2 in human pancreas using APBB2 Polyclonal Antibody (Product # PA5-54816) shows distinct granular positivity in exocrine cells.

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APBB2 Antibody — Antibody specificity was demonstrated by siRNA mediated knockdown of target protein. U2OS cells were transfected with, control siRNA, APBB2 siRNA probe #1, and APBB2 siRNA probe #2 and a decrease in signal intensity was observed in Western Blot application using Anti-APBB2 Polyclonal Antibody (Product # PA5-54816) used at a dilution of 0.4 µg/mL. {KD}

产品信息

PA5-54816

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.04-0.4 µg/mL

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免疫组化（石蜡） (IHC (P))

1:1,000-1:2,500

免疫细胞化学 (ICC/IF)

0.25-2 µg/mL

产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to Human APBB2. Recombinant protein control fragment (Product #RP-102098).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.2 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2638061

产品详细信息

Immunogen sequence: SEKLEGKEPH PQDSSSCEIL PSQPRRTKSF LNYYADLETS ARELEQNRGN HHGTAEEKSQ PVQGQASTII GNGDLLLQKP NRPQSSPEDG QVATVSSSPE TKKDHPKTGA KTDCALHRIQ NLAPS

Highest antigen sequence identity to the following orthologs: Mouse - 85%, Rat - 23%.

靶标信息

The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta precursor protein and amyloid beta precursor-like protein 2. This protein contains two phosphotyrosine binding domains, which are thought to function in signal transduction. Polymorphisms in this gene have been associated with Alzheimer's disease. Alternative splicing results in multiple transcript variants.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

miR‑205‑3p promotes lung cancer progression by targeting APBB2.

Molecular medicine reports

Xu LB,Xiong J,Zhang YH,Dai Y,Ren XP,Ren YJ,Han D,Wei SH,Qi M

Published figure using APBB2 polyclonal antibody (Product # PA5-54816) in Western Blot

Sun Aug 01 00:00:00 EDT 2021

miR‑205‑3p promotes lung cancer progression by targeting APBB2.

Molecular medicine reports

Xu LB,Xiong J,Zhang YH,Dai Y,Ren XP,Ren YJ,Han D,Wei SH,Qi M

Published figure using APBB2 polyclonal antibody (Product # PA5-54816) in Western Blot

Sun Aug 01 00:00:00 EDT 2021

生物信息学

蛋白别名: Amyloid beta precursor protein binding family B member 2; amyloid beta precursor protein-binding family B member 2; Amyloid-beta (A4) precursor protein-binding family B member 2; Fe65-like 1; Protein Fe65-like 1

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基因别名: APBB2; FE65L; FE65L1

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UniProt ID: (Human) Q92870

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Entrez Gene ID: (Human) 323

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功能

beta-amyloid binding protein binding transcription factor binding

参与通路

neuron migration regulation of transcription, DNA-templated cell cycle arrest axon guidance extracellular matrix organization negative regulation of cell growth intracellular signal transduction positive regulation of apoptotic process negative regulation of apoptotic process