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产品信息
A300-980A
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Region between residue 75 and 125 of human adenomatosis polyposis coli.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
tris citrate/phosphate, pH 7-8
内含物
0.09% sodium azide
保存条件
4° C
运输条件
Wet ice
产品详细信息
The recommended shelf life for this product is 1 year from date of receipt.
Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
靶标信息
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: adenomatosis polyposis coli tumor suppressor; Adenomatous polyposis coli protein; Deleted in polyposis 2.5; FPC; Protein APC; protein phosphatase 1, regulatory subunit 46; truncated adenomatosis polyposis coli; WNT signaling pathway regulator
基因别名: APC; BTPS2; DP2; DP2.5; DP3; GS; PPP1R46
UniProt ID: (Human) P25054
Entrez Gene ID: (Human) 324
mitotic cytokinesis
cell fate specification
protein complex assembly
cellular component disassembly involved in execution phase of apoptosis
cellular response to DNA damage stimulus
negative regulation of microtubule depolymerization
cell cycle arrest
mitotic spindle assembly checkpoint
cell adhesion
establishment or maintenance of cell polarity
pattern specification process
negative regulation of cell proliferation
Wnt signaling pathway
cell migration
positive regulation of cell migration
pancreas development
neuron projection development
positive regulation of pseudopodium assembly
regulation of microtubule-based process
response to drug
positive regulation of apoptotic process
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of cell differentiation
positive regulation of protein catabolic process
negative regulation of cyclin-dependent protein serine/threonine kinase activity
regulation of attachment of spindle microtubules to kinetochore
canonical Wnt signaling pathway
bicellular tight junction assembly
negative regulation of canonical Wnt signaling pathway
response to alcohol
beta-catenin destruction complex assembly
beta-catenin destruction complex disassembly
cellular response to nerve growth factor stimulus
regulation of glutamate metabolic process
