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APIP Antibody (MA1-41247) in IHC (P)
Immunohistochemical analysis of APIP in formalin-fixed, paraffin-embedded adenocarcinoma of the breast. Samples were incubated in APIP monoclonal antibody (Product # MA1-41247) using a dilution of 5 µg/mL followed by peroxidase-conjugate and DAB chromogen. Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10 mM sodium citrate buffer, pH 6.0 for 10-20 min followed by cooling at RT ... View More
产品信息
MA1-41247
产品规格
种属反应
Human,
Mouse
宿主/亚型
Mouse
/ IgG2b, kappa
分类
Monoclonal
类型
Antibody
克隆号
19F461
抗原
Recombinant APIP protein.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein G
保存液
PBS with 0.05% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_1070436
产品详细信息
Suggested positive control: HeLa or 293, antigen standard for APIP (transient overexpression lysate).
靶标信息
The mammalian homologues of the key cell death gene CED-4 in C. elegans has been identified recently from human and mouse and designated Apaf 1 (for apoptosis protease-activating factor 1). Apaf 1 binds to cytochrome c (Apaf 2) and Caspase-9 (Apaf 3), which leads to Caspase-9 activation. Activated Caspase-9 in turn cleaves and activates Caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis. Recently, Cho et al (4) have identified a new Apaf 1 Interactiong Protein (APIP) also known as CG129 and MMRP19, as a negative regulator of ischemic injury. APIP competes with Caspase-9 binding site of Apaf 1. APIP is predicted to code for a 204 amino acid. An isoform of APIP, APIP2 encodes a 242 amino acid protein, which is an alternative splicing variant differing in its N-terminus from APIP. APIP transcript is ubiquitously expressed in most adult tissue with high expression in skeletal muscle, heart, and kidney.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: APAF1-interacting protein; APIP; CG129; dJ179L10.2; hAPIP; Methylthioribulose-1-phosphate dehydratase; monocyte macrophage 19; Monocyte/macrophage protein 19; MTRu-1-P dehydratase; probable methylthioribulose-1-phosphate dehydratase
基因别名: APIP; APIP2; CGI-29; CGI29; hAPIP; MMRP19
UniProt ID: (Human) Q96GX9, (Mouse) Q9WVQ5
Entrez Gene ID: (Human) 51074, (Mouse) 56369
apoptotic process
L-methionine biosynthetic process from S-adenosylmethionine
L-methionine biosynthetic process from methylthioadenosine
negative regulation of apoptotic process
protein homotetramerization
pyroptosis
regulation of ERK1 and ERK2 cascade
cellular amino acid biosynthetic process
methionine biosynthetic process
