Bioss

APOC3 Polyclonal Antibody

查看其他20个ApoC3抗体

产品信息

BS-5037R

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:300-1:1,000

-

免疫组化（石蜡） (IHC (P))

1:200

-

免疫组化（冰冻） (IHC (F))

1:100-1:500

-

免疫细胞化学 (ICC/IF)

1:50-1:200

-

酶联免疫吸附实验 (ELISA)

1:500-1:1,000

-

产品规格

种属反应

Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

KLH conjugated synthetic peptide derived from rat Apolipoprotein CIII, amino acids 41-80.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

内含物

0.02% ProClin 300

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

Apolipoprotein C-III, also known as apo-CIII, is a protein that in humans is encoded by the APOC3 gene. Apo-CIII is a component of very low density lipoprotein (VLDL). APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Apo-CIII; Apolipoprotein; apolipoprotein C-3; Apolipoprotein C-III; Apolipoprotein C3; MGC150353

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基因别名: apo-CIII; ApoC-III; Apoc3

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UniProt ID: (Mouse) P33622

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Entrez Gene ID: (Mouse) 11814, (Rat) 24207

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lipid binding lipid transporter activity phospholipid binding enzyme regulator activity lipase inhibitor activity high-density lipoprotein particle receptor binding apolipoprotein

参与通路

lipid metabolic process triglyceride metabolic process triglyceride mobilization transport lipid transport cholesterol metabolic process lipid catabolic process triglyceride catabolic process lipoprotein metabolic process lipoprotein transport response to peptide hormone cellular response to glucose stimulus inflammatory response G-protein coupled receptor signaling pathway response to nutrient negative regulation of triglyceride catabolic process negative regulation of very-low-density lipoprotein particle remodeling negative regulation of very-low-density lipoprotein particle clearance negative regulation of high-density lipoprotein particle clearance negative regulation of low-density lipoprotein particle clearance regulation of Cdc42 protein signal transduction cholesterol efflux phospholipid efflux high-density lipoprotein particle remodeling chylomicron remnant clearance response to drug cholesterol homeostasis negative regulation of fatty acid biosynthetic process negative regulation of lipid metabolic process negative regulation of receptor-mediated endocytosis negative regulation of lipid catabolic process negative regulation of lipoprotein lipase activity negative regulation of cholesterol import triglyceride homeostasis