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Immunogen sequence: IHTPRFSKDH KCSLVFYILS PLNLNSIPDI EQPNVASATK KFSYKLVKTG SVVLTASTDL RGYVVGQALQ LHADVE
Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 92%.
Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates (PubMed:23886940, PubMed:27462458). Through an ubiquitination-dependent mechanism plays for instance a role in the incorporation of SLC11A2 into extracellular vesicles (PubMed:27462458). More generally, plays a role in the extracellular transport of proteins between cells through the release in the extracellular space of microvesicles (PubMed:22315426). By participating in the ITCH-mediated ubiquitination and subsequent degradation of NOTCH1, negatively regulates the NOTCH signaling pathway (PubMed:23886940). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Alpha-arrestin 1; Arrestin domain-containing protein 1
基因别名: ARRDC1
UniProt ID: (Human) Q8N5I2
Entrez Gene ID: (Human) 92714