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Immunogen sequence: RQGGSPAKQ TTWEGGHRVP ALAYWPGRVP VNVTSTALLS VLDIFPTVVA LAQASLPQGR RFDGVDVSEV LFGRSQPGHR VLFHPNSGAA GEFGALQTVR LERYKAFYIT GGARACDGST GPELQHKFPL IFNLEDDTAE AVPLERGGAE YQAVLPEVRK VLADVLQDIA NDNISSADYT QDPSVTPCCN PYQIACRCQA A (326-525 aa encoded by BC012375)
Sulfatases, such as ARSG, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules. This gene, a novel arylsulfatase, has activity toward pseudosubstrates including p-nitrocatechol sulfate and 4-methylumbelliferyl sulfate. Activity is competitively inhibited by phosphate. The unprocessed protein is active as a 63-kDa monomer and demonstrates an acidic pH optimum as typically seen for lysosomal sulfatases. The protein accumulates within lysosomes and is also a glycoprotein that binds specifically to mannose 6-phosphate receptors.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Arylsulfatase G; ASG; N-sulfoglucosamine-3-sulfatase
基因别名: 6330406P08Rik; AI846872; ARSG; KIAA1001; RGD1306571; UNQ839/PRO1777
UniProt ID: (Human) Q96EG1, (Rat) Q32KJ9, (Mouse) Q3TYD4
Entrez Gene ID: (Human) 22901, (Rat) 303631, (Mouse) 74008
分子生物学功能: hydrolase