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ASGR1 Antibody (PA5-32030) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of ASGR1 was performed in HepG2 cells fixed in 4% paraformaldehyde at RT for 15 min. Green: ASGR1 Polyclonal Antibody (Product # PA5-32030) diluted at 1:500. Blue: Hoechst 33342 staining.
产品信息
PA5-32030
产品规格
种属反应
Human,
Mouse
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 25 and 291 of Human ASGPR1
偶联物
Unconjugated
形式
Liquid
浓度
0.3 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol, 1% BSA
内含物
0.025% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2549503
产品详细信息
Recommended positive controls: Huh-7, HepG2, mouse liver.
Predicted reactivity: Rat (80%), Pig (84%), Bovine (82%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
The asialoglycooprotein receptor (ASGPR) is a transmembrane glycoprotein (42 kDa) which mediates binding, internalization and degradation of extracellular glycoproteins that have exposed terminal galactose residues. The receptor is expressed on the surface of the hepatocytes in a polar manner, i. e. it is present on the sinusoidal and lateral plasma membranes but not on the bile canalicular membrane. The mammalian hepatic ASGPR mediate the endocytosis and degradation of serum proteins from which terminal sialic residues have been removed. The rat asialoglycoprotein receptor (ASGPR) consists of three polypeptide subunits: rat hepatic lectin (RHL)-1, RHL-2 and RHL-3. The monoclonal antibody 8D7 recognizes a subunit-specific epitope of RHL-1 of rat ASGPR. The monoclonal antibody 8D7 is cross reactive with human ASGPR.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: ASGP-R 1; ASGPR 1; Asialoglycoprotein receptor 1; C-type lectin domain family 4 member H1; Hepatic lectin 1; Hepatic lectin H1; HL-1
基因别名: ASGPR; ASGPR1; Asgr; Asgr-1; ASGR1; CLEC4H1; HL-1
UniProt ID: (Human) P07306, (Mouse) P34927
Entrez Gene ID: (Human) 432, (Mouse) 11889
