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Product Details
A301-749A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 2919 and 2969 of human absent, small and homeotic disks protein 1.
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
tris citrate/phosphate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4° C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Target Information
ASH1 (ASH1L) is a member of the trithorax group of transcriptional activators. The protein contains four AT hooks, a SET domain, a PHD-finger motif, and a bromodomain. It is localized to many small speckles in the nucleus, and also to cell-cell tight junctions. Diseases associated with ASH1 include Mental Retardation, Autosomal Dominant 52 and Pulpitis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Absent small and homeotic disks protein 1 homolog; absent, small, or homeotic discs 1; ash1 (absent, small, or homeotic)-like; ASH1-like protein; chromatin remodeling factor; Histone-lysine N-methyltransferase ASH1L; huASH1; Lysine N-methyltransferase 2H; probable histone-lysine N-methyltransferase ASH1L
Gene Aliases: 8030453L17Rik; ASH1; ASH1L; ASH1L1; E430018P19Rik; KIAA1420; KMT2H
UniProt ID: (Human) Q9NR48, (Mouse) Q99MY8
Entrez Gene ID: (Human) 55870, (Mouse) 192195
DNA binding
chromatin binding
zinc ion binding
histone methyltransferase activity (H3-K4 specific)
histone methyltransferase activity (H3-K36 specific)
methyltransferase activity
transferase activity
histone-lysine N-methyltransferase activity
metal ion binding
chromatin/chromatin-binding, or -regulatory protein
histone modifying enzyme
negative regulation of acute inflammatory response
DNA packaging
transcription from RNA polymerase II promoter
cell-cell signaling
interleukin-6 production
negative regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of MAPK cascade
positive regulation of transcription from RNA polymerase II promoter
histone H3-K4 methylation
histone H3-K36 dimethylation
transcription, DNA-templated
regulation of transcription, DNA-templated
chromatin modification
methylation
negative regulation of inflammatory response
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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