Bioss

ASL/Argininosuccinate Lyase Polyclonal Antibody

查看其他12个ASL抗体

产品信息

BS-12515R

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

-

免疫组化（石蜡） (IHC (P))

1:50-1:200

-

免疫组化（冰冻） (IHC (F))

1:100-1:500

-

免疫细胞化学 (ICC/IF)

1:100-1:500

-

酶联免疫吸附实验 (ELISA)

1:500-1:1,000

-

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

KLH conjugated synthetic peptide derived from human ASL/Argininosuccinate Lyase, amino acids 301-400.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

内含物

0.02% ProClin 300

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

ASL encodes a member of the lyase 1 family. The encoded protein forms a cytosolic homotetramer and primarily catalyzes the reversible hydrolytic cleavage of argininosuccinate into arginine and fumarate, an essential step in the liver in detoxifying ammonia via the urea cycle. Mutations in this gene result in the autosomal recessive disorder argininosuccinic aciduria, or argininosuccinic acid lyase deficiency. A nontranscribed pseudogene is also located on the long arm of chromosome 22. Alternatively spliced transcript variants encoding different isoforms have been described.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: argininosuccinase; Argininosuccinate lyase; Arginosuccinase; ASAL

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基因别名: 2510006M18Rik; ASAL; ASL

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UniProt ID: (Human) P04424, (Mouse) Q91YI0, (Rat) P20673

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Entrez Gene ID: (Human) 435, (Mouse) 109900, (Rat) 59085

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argininosuccinate lyase activity protein binding catalytic activity lyase activity lyase metabolite interconversion enzyme

参与通路

urea cycle internal protein amino acid acetylation arginine biosynthetic process arginine catabolic process arginine biosynthetic process via ornithine protein tetramerization argininosuccinate metabolic process liver development cellular amino acid metabolic process locomotory behavior cellular amino acid biosynthetic process post-embryonic development ammonia assimilation cycle kidney development midgut development aging response to nutrient response to toxic substance response to zinc ion response to amine response to lipopolysaccharide response to drug response to peptide hormone response to steroid hormone response to growth hormone diaphragm development cellular response to ammonium ion cellular response to cAMP cellular response to interferon-gamma cellular response to tumor necrosis factor cellular response to glucagon stimulus cellular response to glucocorticoid stimulus cellular response to hypoxia cellular response to dexamethasone stimulus