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ASXL1 Antibody (PA5-71475) in ICC/IF
Immunocytochemistry analysis of ASXL1 in HeLa cells. Samples were incubated in ASXL1 polyclonal antibody (Product # PA5-71475) followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). Actin filaments have been labeled with Alexa Fluor555 phalloidin (red). DAPI was used to stain the cell nuclear (blue).
产品信息
PA5-71475
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide between 521-549 amino acids from the Central region of human ASXL1
偶联物
形式
Liquid
浓度
0.3 mg/mL
纯化类型
Protein A, Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2717329
靶标信息
Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator of RARA and RXRA through association with NCOA1. Acts as corepressor through recruitment of KDM1A and CBX5 to target genes in a cell-type specific manner; the function seems to involve differential recruitment of methylated histone H3 to respective promoters. Acts as corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: additional sex combs like 1; additional sex combs like transcriptional regulator 1; Additional sex combs-like protein 1; MGC117280; MGC71111; Polycomb group protein ASXL1; putative Polycomb group protein ASXL1
基因别名: ASXL1; BOPS; KIAA0978; MDS; mKIAA0978
UniProt ID: (Human) Q8IXJ9, (Mouse) P59598
Entrez Gene ID: (Human) 171023, (Mouse) 228790
negative regulation of transcription from RNA polymerase II promoter
heart morphogenesis
transcription, DNA-templated
response to retinoic acid
negative regulation of peroxisome proliferator activated receptor signaling pathway
monoubiquitinated histone H2A deubiquitination
negative regulation of fat cell differentiation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of retinoic acid receptor signaling pathway
negative regulation of retinoic acid receptor signaling pathway
bone development
lung saccule development
regulation of transcription, DNA-templated
chromatin modification
