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Positive test controls include: HeLa, HCT116, 293T, SH-SY5Y, Neuro-2a, Mouse testis, Rat testis. The target is usually found in the following locations: Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum membrane, Peripheral membrane protein, Preautophagosomal structure membrane, autophagosome membrane.
Immunogen sequence: SKQKFTRAVK KLNANILYLC FSQHVNLDQL QPLHTLRNLM YLVSPSSEHL GRSGPFEVRA DLEESMEFVD PGVAGESDES GDERVSDEET DLGTDWENLP S
ATG14 (Autophagy related protein homolog 14) is encoded by the ATG14 gene and is located on chromosome 14 in humans. It is also known as ATG14L or BARKOR (Beclin 1-associated autophagy-related key regulator). Autophagy is an evolutionarily conserved process that involves recycling of misfolded cellular proteins and degradation of dysfunctional organelles. Autophagy is induced as a cellular response to nutrient stress which includes the formation of autophagosomes, fusion of these with the lysosome and formation of the autophagolysosome. The Class III PI3-Kinase, Vps34 and its interacting partner Beclin 1 have been shown to form a complex which specifically includes ATG 14 (type 1) or UVRAG (type 2). Atg 14 guides the type 1 complex to the preautophagosomal structure (PAS) and is critical for the initiation of autophagosome formation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: ATG14 autophagy related 14 homolog; Atg14-like protein; Atg14L; Autophagy-related protein 14-like protein; Bakor; Barkor; Beclin 1-associated autophagy-related key regulator; Beclin 1-Interacting protein; VATG14 autophagy related 14 homolog
基因别名: 4832427M01; ATG14; ATG14L; BARKOR; D14Ertd114e; D14Ertd436e; KIAA0831; RGD1304610
UniProt ID: (Human) Q6ZNE5, (Mouse) Q8CDJ3, (Rat) D4A4K3
Entrez Gene ID: (Human) 22863, (Mouse) 100504663, (Rat) 305831