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产品信息
H00000474-M05
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
3E2
抗原
ATOH1 (NP_005163.1, 266 a.a. approximately 354 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: PTPPGSCRTR FSAPASAGGY SVQLDALHFS TFEDSALTAM MAQKNLSPSL PGSILQPVQE ENSKTSPRSH RSDGEFSPHS HYSDSDEAS
靶标信息
The Drosophila atonal gene produces a protein with basic helix loop helix (bHLH) domains that plays an essential role in the development of the Drosophila nervous system. Mammalian atonal homolog 1 (MATH-1) is a helix-loop-helix (HLH) transcription factor that is structurally homologous to the product of the Drosophila proneural gene atonal. MATH-1, so known as Atoh1, Ath1 or HATH-1, is a 351 amino acid protein with an atonal-related basic HLH domain. In mice, expression of MATH-1 takes place by embryonic day 9. 5 and initially localizes to the cranial ganglions and the dorsal part of the central nervous system. Prominent expression of MATH-1 is in the dorsal part of the central nervous system but becomes restricted to the external granular layer of the cerebellum by day 18 and is undetectable in the adult nervous system. It is suggested that MATH-1 may play a role in the differentiation of subsets of neural cells by activating E box-dependent transcription.
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生物信息学
蛋白别名: Atonal bHLH transcription factor 1; atonal homolog 1; atonal homolog bHLH transcription factor 1; bHLHa14; Class A basic helix-loop-helix protein 14; H MATH-1; hATH1; Helix-loop-helix protein hATH-1; Protein atonal homolog 1; Transcription factor ATOH1
基因别名: ATH1; ATOH1; BHLHA14; HATH1; MATH-1
UniProt ID: (Human) Q92858
Entrez Gene ID: (Human) 474
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
chromatin DNA binding
protein dimerization activity
basic helix-loop-helix transcription factor
neuron migration
transcription from RNA polymerase II promoter
Notch signaling pathway
axon guidance
central nervous system development
cerebral cortex development
inner ear morphogenesis
auditory receptor cell fate specification
auditory receptor cell fate determination
negative regulation of apoptotic process
positive regulation of auditory receptor cell differentiation
positive regulation of neuron differentiation
positive regulation of transcription from RNA polymerase II promoter
