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产品信息
PA5-86532
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide, corresponding to the N-terminus of Rat Na+/K+-ATPase alpha1.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2803306
产品详细信息
Purity is > 95% by SDS-PAGE.
靶标信息
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene.
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生物信息学
蛋白别名: ATP1B; ATPase, Na+/K+ transporting, alpha 1 polypeptide; ATPase, Na+K+ transporting, alpha 1; MGC1798; Na(+)/K(+) ATPase alpha-1 subunit; Na+/K+ ATPase 1; Na+/K+ ATPase Alpha; Na, K-ATPase, alpha-A catalytic polypeptide; Na,K-ATPase alpha-1 subunit; Na,K-ATPase catalytic subunit alpha-A protein; RP4-655J12.1; Sodium Potassium ATPase; Sodium pump subunit alpha-1; sodium-potassium ATPase catalytic subunit alpha-1; sodium-potassium-ATPase, alpha 1 polypeptide; Sodium/potassium-transporting ATPase subunit alpha-1
基因别名: ATP1A1; Atpa-1; BC010319; Nkaa1b
UniProt ID: (Human) P05023, (Rat) P06685, (Mouse) Q8VDN2
Entrez Gene ID: (Human) 476, (Rat) 24211, (Mouse) 11928
sodium:potassium-exchanging ATPase activity
protein binding
ATP binding
phosphatase activity
protein kinase binding
protein domain specific binding
ankyrin binding
potassium ion binding
sodium ion binding
ADP binding
phosphatidylinositol 3-kinase binding
chaperone binding
steroid hormone binding
nucleotide binding
hydrolase activity
metal ion binding
primary active transporter
regulation of the force of heart contraction
regulation of sodium ion transport
cellular sodium ion homeostasis
regulation of blood pressure
potassium ion import
establishment or maintenance of transmembrane electrochemical gradient
ATP hydrolysis coupled proton transport
dephosphorylation
cellular potassium ion homeostasis
negative regulation of glucocorticoid biosynthetic process
ion transmembrane transport
sodium ion export from cell
response to drug
negative regulation of heart contraction
positive regulation of heart contraction
positive regulation of striated muscle contraction
relaxation of cardiac muscle
cardiac muscle contraction
membrane hyperpolarization
cellular response to mechanical stimulus
cellular response to steroid hormone stimulus
regulation of cardiac muscle cell contraction
membrane repolarization
membrane repolarization during cardiac muscle cell action potential
cell communication by electrical coupling involved in cardiac conduction
response to glycoside
regulation of cardiac conduction
potassium ion import across plasma membrane
potassium ion transport
sodium ion transport
energy coupled proton transmembrane transport, against electrochemical gradient
sodium ion transmembrane transport
potassium ion transmembrane transport
transport
ion transport
