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产品信息
28030-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Not Applicable
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
ATP1A3 (middle) Fusion Protein Ag27705 (378-580 aa encoded by BC015566)
偶联物
形式
Liquid
浓度
0.27 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
This antibody is generated against the middle region (378-580aa) of ATP1A3 and detects 113 kDa protein in SDS-PAGE.
Immunogen sequence: VAHMWFDNQ IHEADTTEDQ SGTSFDKSSH TWVALSHIAG LCNRAVFKGG QDNIPVLKRD VAGDASESAL LKCIELSSGS VKLMRERNKK VAEIPFNSTN KYQLSIHETE DPNDNRYLLV MKGAPERILD RCSTILLQGK EQPLDEEMKE AFQNAYLELG GLGERVLGFC HYYLPEEQFP KGFAFDCDDV NFTTDNLCFV GLMS (378-580 aa encoded by BC015566)
靶标信息
The sodium/potassium ATPase is an integral membrane enzyme found in all cells of higher organisms and is responsible for the ATP-dependent transport of sodium and potassium across the cell membrane. This membrane-bound enzyme is related to a number of other ATPases including sarcoplasmic and endoplasmic reticulum calcium ATPase (SERCA) and plasma membrane calcium ATPase (PMCA). The sodium/potassium ATPase consists of a large, multipass, transmembrane catalytic subunit, termed the alpha subunit, and an associated smaller glycoprotein, termed the beta subunit. Studies indicate that there are three isoforms of the alpha subunit (alpha 1, alpha 2, alpha 3) and two isoforms of the beta subunit (beta 1 and beta 2) encoded by two multigene families. The different isoforms of the sodium/potassium ATPase exhibit tissue-specific and developmental patterns of expression. The alpha 1 and beta mRNAs are present in all cell types examined, whereas the alpha 2 and alpha 3 mRNAs exhibit a more restricted pattern of cell-specific expression. The alpha-3 subunit has been found in neuronal and to skeletal and cardiac muscle, lung and stomach tissues.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: ATPase, Na+/K+ transporting, alpha 3 polypeptide; EC 3.6.3.9; Na(+)/K(+) ATPase alpha(III) subunit; Na(+)/K(+) ATPase alpha-3 subunit; Na+, K+ activated adenosine triphosphatase alpha subunit; Na+/K+ ATPase 3; Sodium Potassium ATPase; Sodium pump 3; Sodium pump subunit alpha-3; sodium-potassium ATPase catalytic subunit alpha-3; sodium-potassium-ATPase, alpha 3 polypeptide; sodium/potassium-transporting ATPase alpha-3 chain; Sodium/potassium-transporting ATPase subunit alpha-3
基因别名: AHC2; ATP1A1; ATP1A3; CAPOS; DYT12; RDP
UniProt ID: (Human) P13637
Entrez Gene ID: (Human) 478
sodium:potassium-exchanging ATPase activity
ATP binding
D1 dopamine receptor binding
heparan sulfate proteoglycan binding
metal ion binding
chaperone binding
sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential
steroid hormone binding
primary active transporter
cellular sodium ion homeostasis
memory
adult locomotory behavior
visual learning
potassium ion import
establishment or maintenance of transmembrane electrochemical gradient
ATP hydrolysis coupled proton transport
cellular potassium ion homeostasis
ion transmembrane transport
ionotropic glutamate receptor signaling pathway
sodium ion export from cell
response to drug
cardiac muscle contraction
cellular response to steroid hormone stimulus
regulation of cardiac muscle cell membrane potential
cell communication by electrical coupling involved in cardiac conduction
response to glycoside
regulation of cardiac conduction
