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产品信息
PA5-92342
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 26-106 of human ATPIF1 (NP_0573951)
偶联物
形式
Liquid
浓度
0.93 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2806444
产品详细信息
Immunogen sequence: GSDQSENVDR GAGSIREAGG AFGKREQAEE ERYFRAQSRE QLAALKKHHE EEIVHHKKEI ERLQKEIERH KQKIKMLKHD D; Positive Samples: MCF-7, 22Rv1, HeLa, H460, Mouse brain; Cellular Location: Mitochondrion
靶标信息
Complex V, also called F1F0 ATPase or ATP synthase is extremely conserved through evolution and can be found in plants, fungi, bacteria, and animals. The ATP synthase enzyme is a transmembrane protein responsible for driving the reversible reaction from ADP + phosphate to ATP, in oxidative phosphorylation, and as a proton pumping ATPase. This reaction is accomplished by a flux of protons across the membrane as a result of electron transfer. The enzyme was thought to be localized exclusively to mitochondria; however, it has recently been identified on the plasma membrane of several cell types including hepatocytes where it functions as the HDL receptor, on endothelial cells where it may act as the angiostatin receptor, and on the surface of cancer cells. The ATP synthase protein has two main sections; the F1 ATP-ase (soluble) and the F0 ATP-ase (membrane embedded). The F1 section consists of the alpha, beta, gamma, delta, and epsilon subunits; while the F0 consists of a, b, and c subunits. The enzyme in mammals is composed of 17 subunits, five of which make up the easily detached F1. The remainder subunits are components of two stalk domains and the proton pumping F0 part of the machinery. Two of the subunits of the F0 part are encoded on mitochondrial DNA while the other subunits are nuclearly encoded. Mutations in the mitochondrial-encoded subunits of ATP synthase (Complex V) cause OXPHOS disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ATP synthase F1 subunit epsilon; ATP synthase inhibitor protein; ATPase inhibitor protein; ATPase inhibitor, mitochondrial; IF(1); IF1; Inhibitor of F(1)F(o)-ATPase
基因别名: ATP5IF1; ATPI; ATPIF1; ATPIP; IF(1); If1; IP
UniProt ID: (Human) Q9UII2, (Mouse) O35143
Entrez Gene ID: (Human) 93974, (Mouse) 11983
angiogenesis
negative regulation of endothelial cell proliferation
generation of precursor metabolites and energy
heme biosynthetic process
folic acid-containing compound biosynthetic process
erythrocyte differentiation
negative regulation of ATPase activity
tetrahydrofolate interconversion
protein homooligomerization
protein homotetramerization
negative regulation of hydrolase activity
mitochondrial depolarization
reactive oxygen species metabolic process
mitophagy in response to mitochondrial depolarization
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
positive regulation of proteolysis involved in cellular protein catabolic process
regulation of protein targeting to mitochondrion
regulation of ATP metabolic process
