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产品信息
PA5-61999
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.4 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2638392
产品详细信息
Immunogen sequence: KHPESEWPFL IITDLFLKSP ELVQAMFPKL NNQERVTLLD LMIAKITSDE PLTKDDIPVF LRHAELIAST F
Highest antigen sequence identity to the following orthologs: Mouse - 72%, Rat - 82%.
靶标信息
The autosomal dominant cerebellar ataxias (ADCAs) are a clinically and genetically heterogeneous group of disorders characterized by ataxia, dysarthria, dysmetria, and intention tremor. All ADCAs involve some degree of cerebellar dysfunction and a varying degree of signs from other components of the nervous system. A commonly accepted clinical classification (Harding, 1993) divides ADCAs into 3 different groups based on the presence or absence of associated symptoms such as brainstem signs or retinopathy. The presence of pyramidal and extrapyramidal symptoms and ophthalmoplegia makes the diagnosis of ADCA I, the presence of retinopathy points to ADCA II, and the absence of associated signs to ADCA III. Genetic linkage and molecular analyses revealed that ADCAs are genetically heterogeneous even within the various subtypes.
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生物信息学
蛋白别名: Ataxin-10; Brain protein E46 homolog; Spinocerebellar ataxia type 10 protein
基因别名: ATXN10; E46L; HUMEEP; SCA10
UniProt ID: (Human) Q9UBB4
Entrez Gene ID: (Human) 25814
