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产品信息
PA5-70603
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
synthetic peptide directed towards the middle region of human V1b Receptor (aa 363-412)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2690593
产品详细信息
This target displays homology in the following species: Human: 100%
靶标信息
Vasopressin V1B receptor expression has been documented in the pituitary, pituitary tumors, pheochromocytoma, breast cancer, and small-cell lung carcinomas. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This turn-off activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
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生物信息学
蛋白别名: Antidiuretic hormone receptor 1b; arginine vasopressin receptor 3; AVPR V1b; AVPR V3; pituitary vasopressin receptor 3; V1b receptor; V1bR; Vasopressin V1b receptor; Vasopressin V3 receptor
基因别名: AVPR1B; AVPR3; VPR3
UniProt ID: (Human) P47901
Entrez Gene ID: (Human) 553
regulation of systemic arterial blood pressure by vasopressin
G-protein coupled receptor signaling pathway
activation of phospholipase C activity
positive regulation of cytosolic calcium ion concentration
cellular response to hormone stimulus
positive regulation of vasoconstriction
response to peptide
