Proteintech

AXIN1 Polyclonal Antibody

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AXIN1 Antibody (16541-1-AP) in WB

HT-1080 cells were subjected to SDS PAGE followed by western blot with 16541-1-AP (AXIN1 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

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产品信息

16541-1-AP

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

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其他PubMed (Misc)

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不适用 (N/A)

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产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

AXIN1 Fusion Protein Ag9858 (1-351 aa encoded by BC044648)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.16 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Proteintech's AXIN1 antibody 16541-1-AP is a rabbit polyclonal antibody raised against the N-terminus of human AXIN1.

Immunogen sequence: MNIQEQGFP LDLGASFTED APRPPVPGEE GELVSTDPRP ASYSFCSGKG VGIKGETSTA TPRRSDLDLG YEPEGSASPT PPYLKWAESL HSLLDDQDGI SLFRTFLKQE GCADLLDFWF ACTGFRKLEP CDSNEEKRLK LARAIYRKYI LDNNGIVSRQ TKPATKSFIK GCIMKQLIDP AMFDQAQTEI QATMEENTYP SFLKSDIYLE YTRTGSESPK VCSDQSSGSG TGKGISGYLP TLNEDEEWKC DQDMDEDDGR DAAPPGRLPQ KLLLETAAPR VSSSRRYSEG REFRYGSWRE PVNPYYVNAG YALAPATSAN DSEQQSLSSD ADTLSLTDSS VDGIPPYRIR KQ (1-351 aa encoded by BC044648)

靶标信息

AXIN1 is a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a disheveled and axin (DIX) domain and is thought to function as a negative regulator of the WNT signaling pathway that regulates embryonic axis formation. AXIN1 interacts with adenomatosis polyposis coli (APC), beta-catenin, glycogen synthase kinase 3 beta, forming a tetrameric complex resulting in the regulation of the stabilization of beta-catenin. Mutations in the AXIN1 gene have been associated various carcinomas, indicating that it also functions as a tumor suppressor.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: Axin-1; Axis inhibition protein 1; axis inhibitor 1; fused, mouse, homolog of; hAxin; LA16c-314G4.3; MGC52315; protein phosphatase 1, regulatory subunit 49

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基因别名: AXIN; AXIN1; PPP1R49

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UniProt ID: (Human) O15169

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Entrez Gene ID: (Human) 8312

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