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Abl2 Antibody (MA5-37673) in IHC (P)
Immunohistochemistry (Paraffin) analysis of Abl2 in human colon tissue sections using the Abl2 Monoclonal Antibody (Product # MA5-37673) at a dilution of 1:25. Tissue was fixed with formaldehyde and blocked with 3% BSA for 0. 5 hour at room temperature; antigen retrieval was by heat mediation with a citrate buffer (pH6). Samples were incubated with primary antibody (1:25) for 1 hours at 37°C. A undiluted bi... View More
产品信息
MA5-37673
产品规格
种属反应
Human,
Mouse
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
1442CT175.30.33
抗原
recombinant protein Abl2
偶联物
形式
Liquid
浓度
0.48 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2897597
靶标信息
ABL2 (Arg) is an Abl-related non-receptor protein tyrosine kinase that links cell surface receptors to cell proliferation and/or cytoskeletal reorganization. Abl2 encodes a member of the Abelson family of nonreceptor tyrosine protein kinase. The protein is highly similar to the ABL1 protein, including the tyrosine kinase, SH2 and SH3 domains, and has a role in cytoskeletal rearrangements by its C-terminal F-actin- and microtubule-binding sequences. Abl2 is expressed in both normal and tumor cells, and is involved in translocation with the ETV6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Abelson murine leukemia viral oncogene homolog 2; Abelson tyrosine-protein kinase 2; Abelson-related gene protein; abl2; c-abl oncogene 2, non-receptor tyrosine kinase; FLJ22224; FLJ31718; FLJ41441; tyrosine kinase ARG; Tyrosine-protein kinase ABL2; Tyrosine-protein kinase ARG; v-abl Abelson murine leukemia viral oncogene homolog 2; v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)
基因别名: AA536808; ABL2; ABLL; ARG
UniProt ID: (Human) P42684
Entrez Gene ID: (Human) 27, (Mouse) 11352
magnesium ion binding
actin monomer binding
protein kinase activity
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
receptor binding
protein binding
ATP binding
manganese ion binding
actin filament binding
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
metal ion binding
cellular protein modification process
cell adhesion
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
positive regulation of cytosolic calcium ion concentration
regulation of autophagy
positive regulation of phospholipase C activity
positive regulation of neuron projection development
cell migration
peptidyl-tyrosine phosphorylation
actin cytoskeleton organization
regulation of endocytosis
regulation of cell adhesion
peptidyl-tyrosine autophosphorylation
regulation of cell proliferation
innate immune response
positive regulation of oxidoreductase activity
cellular response to retinoic acid
regulation of cell motility
regulation of actin cytoskeleton reorganization
protein phosphorylation
phagocytosis
substrate-dependent cell migration, cell extension
actin filament organization
epidermal growth factor receptor signaling pathway
learning
visual learning
phosphorylation
neuron remodeling
cerebellum morphogenesis
negative regulation of cell-cell adhesion
positive regulation of protein binding
cellular protein localization
negative regulation of Rho protein signal transduction
exploration behavior
positive regulation of I-kappaB kinase/NF-kappaB signaling
alpha-beta T cell differentiation
platelet-derived growth factor receptor signaling pathway
dendrite morphogenesis
neuromuscular process controlling balance
actin filament bundle assembly
Bergmann glial cell differentiation
positive regulation of ERK1 and ERK2 cascade
dendritic spine maintenance
positive regulation of interleukin-2 secretion
positive regulation of interferon-gamma secretion
regulation of extracellular matrix organization
positive regulation of Wnt signaling pathway, planar cell polarity pathway
negative regulation of endothelial cell apoptotic process
