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产品信息
BS-0611R-CY5
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide derived from human Adiponectin receptor 2
偶联物
激发/发射光谱
647/665 nm
查看光谱
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
TBS, pH 7.4, with 50% glycerol, 1% BSA
内含物
0.03% ProClin 300
保存条件
-20°C or -80°C if preferred
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Adiponectin (also known as 30-kDa adipocyte complement-related protein; Acrp30) is a hormone secreted by adipocytes that acts as an antidiabetic and anti-atherogenic adipokine. Levels of adiponectin in the blood are decreased under conditions of obesity, insulin resistance and type 2 diabetes. Administration of adiponectin causes glucose-lowering effects and ameliorates insulin resistance in mice. Conversely, adiponectin-deficient mice exhibit insulin resistance and diabetes. This insulin-sensitizing effect of adiponectin seems to be mediated by an increase in fatty-acid oxidation through activation of AMP kinase and PPAR. Here we report the cloning of complementary DNAs encoding adiponectin receptors 1 and 2 (AdipoR1 and AdipoR2) by expression cloning. AdipoR1 is abundantly expressed in skeletal muscle, whereas AdipoR2 is predominantly expressed in the liver. These two adiponectin receptors are predicted to contain seven transmembrane domains, but are structurally and functionally distinct from G-protein-coupled receptors. Expression of AdipoR1/R2 or suppression of AdipoR1/R2 expression by small-interfering RNA supports our conclusion that they serve as receptors for globular and full-length adiponectin, and that they mediate increased AMP kinase and PPAR- ligand activities, as well as fatty-acid oxidation and glucose uptake by adiponectin.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Adiponectin receptor protein 2; FLJ21432; MGC4640; Progestin and adipoQ receptor family member 2; Progestin and adipoQ receptor family member II
基因别名: 1110001I14Rik; ACDCR2; ADCR2; ADIPOR2; AI115388; AW554121; D6Ucla1e; PAQR2; Parq2
UniProt ID: (Human) Q86V24, (Mouse) Q8BQS5
Entrez Gene ID: (Human) 79602, (Rat) 312670, (Mouse) 68465
G-protein coupled receptor signaling pathway
heart development
female pregnancy
response to nutrient
hormone-mediated signaling pathway
fatty acid oxidation
negative regulation of cell growth
adiponectin-activated signaling pathway
glucose homeostasis
positive regulation of glucose import
vascular wound healing
lipid metabolic process
fatty acid metabolic process
