Invitrogen

Ankyrin B Monoclonal Antibody (N105/13), PerCP

查看其他7个Ankyrin B抗体
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产品信息

MA5-45528

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000
-

免疫组化 (IHC)

1:200
-

免疫细胞化学 (ICC/IF)

1:200
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

N105/13

抗原

Synthetic peptide amino acids 203-496 of human Ankyrin-B
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偶联物

PerCP PerCP PerCP

激发/发射光谱

482/675 nm 查看光谱 spectra

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein G

保存液

47.35mM phosphate/2.15mM MES, pH 7.4, with 2mM EDTA, 0.17066µM Pentachlorophenol, 0.8mM ethanol

内含物

no preservative

保存条件

4° C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2931982

产品详细信息

1 µg/mL of MA5-45528 was sufficient for detection of Ankyrin-B in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.|Detects approximately 200kDa. No cross reactivity against Ankyrin-G.

This antibody was formerly sold as clone S105-13.

靶标信息

This gene encodes a member of the ankyrin family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton. Ankyrins play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. The protein encoded by this gene is required for targeting and stability of Na/Ca exchanger 1 in cardiomyocytes. Mutations in this gene cause long QT syndrome 4. Multiple transcript variants encoding different isoforms have been described.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: ANK-2; ank2; ankyrin 2, brain; ankyrin 3, epithelial; ankyrin B; ankyrin, brain; Ankyrin-2; ankyrin-2, nonerythrocytic; Ankyrin-B; Brain ankyrin; Non-erythroid ankyrin

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基因别名: AI835472; ANK-2; ANK2; Ank3; ANKB; AW491075; brank-2; LQT4

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UniProt ID: (Human) Q01484, (Mouse) Q8C8R3

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Entrez Gene ID: (Human) 287, (Mouse) 109676, (Rat) 362036

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功能
structural constituent of cytoskeleton protein binding cytoskeletal adaptor activity enzyme binding protein kinase binding spectrin binding protein binding, bridging ion channel binding ATPase binding potassium channel regulator activity membrane traffic protein scaffold/adaptor protein
参与通路
regulation of heart rate atrial septum development cellular calcium ion homeostasis ER to Golgi vesicle-mediated transport cytoskeleton organization positive regulation of gene expression regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion regulation of cardiac muscle contraction by calcium ion signaling paranodal junction assembly regulation of protein stability T-tubule organization protein localization to organelle protein localization to cell surface cellular protein localization protein localization to M-band protein localization to T-tubule positive regulation of potassium ion transport protein stabilization regulation of release of sequestered calcium ion into cytosol response to methylmercury regulation of calcium ion transport positive regulation of calcium ion transport regulation of cardiac muscle contraction regulation of ventricular cardiac muscle cell membrane repolarization sarcoplasmic reticulum calcium ion transport protein localization to endoplasmic reticulum protein localization to plasma membrane protein targeting to plasma membrane regulation of cardiac muscle cell contraction ventricular cardiac muscle cell action potential atrial cardiac muscle cell action potential SA node cell action potential membrane depolarization during SA node cell action potential atrial cardiac muscle cell to AV node cell communication SA node cell to atrial cardiac muscle cell communication regulation of heart rate by cardiac conduction regulation of SA node cell action potential regulation of atrial cardiac muscle cell action potential positive regulation of potassium ion transmembrane transporter activity regulation of calcium ion transmembrane transporter activity positive regulation of calcium ion transmembrane transporter activity positive regulation of cation channel activity signal transduction protein localization regulation of apoptotic process cardiac muscle contraction regulation of cardiac muscle cell membrane potential regulation of AV node cell action potential regulation of cation channel activity nervous system development
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