Fabgennix

Axin 2 Polyclonal Antibody, Biotin

查看其他12个AXIN2抗体

产品信息

AXIN2-BIOTIN

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

-

免疫组化 (IHC)

1:50-1:250

-

酶联免疫吸附实验 (ELISA)

1:10,000

-

免疫沉淀 (IP)

1:50-1:250

-

产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide taken within amino acid region 800-843 on human Axin 2 protein.

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偶联物

Biotin Biotin Biotin

形式

Liquid

浓度

0.5-1.5 mg/mL

纯化类型

Affinity chromatography

保存液

proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Axil; Axin like protein; Axin-2; Axin-like protein; Axis inhibition protein 2; Conductin; DKFZp781B0869; MGC10366; MGC126582

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基因别名: Axi1; AXIL; AXIN2; Conductin; ODCRCS

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UniProt ID: (Human) Q9Y2T1, (Mouse) O88566

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Entrez Gene ID: (Human) 8313, (Mouse) 12006

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GTPase activator activity protein binding beta-catenin binding enzyme binding protein kinase binding ubiquitin protein ligase binding armadillo repeat domain binding I-SMAD binding scaffold/adaptor protein

参与通路

positive regulation of protein phosphorylation intramembranous ossification secondary heart field specification chondrocyte differentiation involved in endochondral bone morphogenesis regulation of transcription, DNA-templated cell proliferation negative regulation of cell proliferation dorsal/ventral axis specification positive regulation of epithelial to mesenchymal transition positive regulation of cell death Wnt signaling pathway bone mineralization regulation of mismatch repair cellular protein localization negative regulation of catenin import into nucleus odontogenesis positive regulation of GTPase activity maintenance of DNA repeat elements negative regulation of osteoblast differentiation mRNA stabilization regulation of chondrocyte development regulation of centromeric sister chromatid cohesion cellular response to organic cyclic compound negative regulation of canonical Wnt signaling pathway Wnt signaling pathway involved in somitogenesis positive regulation of canonical Wnt signaling pathway beta-catenin-TCF complex assembly somitogenesis cell death regulation of Wnt signaling pathway regulation of catenin import into nucleus termination of G-protein coupled receptor signaling pathway positive regulation of protein kinase activity negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification