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B4galt1 Antibody (A01890-40) in WB
Independent validation of Mouse B4galt1 Antibody (11H3) (GenScript, A01890-40) and Mouse B4galt1 Antibody (3C9) (GenScript, A01889-40) with Mouse B4galt1 recombinant protein. Lane 1: 50 ng Mouse B4galt1 recombinant protein Lane 2: 25 ng Mouse B4galt1 recombinant protein Lane 3: 10 ng Mouse B4galt1 recombinant protein Lane 4: 50 ng Mouse B4galt1 recombinant protein Lane 5: 25 ng Mouse B4galt1 recombinant protein Lane 6: 10 ng Mouse B4galt1 recombinant protein Primary Antibody: Lane 1~3: Mouse B4galt1 Antibody (3C9) (GenScript, A01889-40) 1 ... View More
产品信息
A01890-40
产品规格
宿主/亚型
Mouse
/ IgG1, lambda
分类
Monoclonal
类型
Antibody
克隆号
11H3
抗原
Recombinant Mouse B4galt1
偶联物
形式
Lyophilized
保存条件
-20°C or -80°C if preferred
运输条件
Wet ice
产品详细信息
Reconstitute the lyophilized antibody with deionized water (or equivalent) to a final concentration of 0.5 mg/ml.
B4GALT1 (Beta-1,4-Galactosyltransferase 1) is a protein coding gene. Among its related pathways are transport to the Golgi and subsequent modification and metabolism. B4galt1 is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose. The Golgi complex form catalyzes the production of lactose in the lactating mammary gland and could also be responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. The cell surface form functions as a recognition molecule during a variety of cell to cell and cell to matrix interactions, as those occurring during development and egg fertilization, by binding to specific oligosaccharide ligands on opposing cells or in the extracellular matrix.
靶标信息
This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene is unique among the beta4GalT genes because it encodes an enzyme that participates both in glycoconjugate and lactose biosynthesis. For the first activity, the enzyme adds galactose to N-acetylglucosamine residues that are either monosaccharides or the nonreducing ends of glycoprotein carbohydrate chains. The second activity is restricted to lactating mammary tissues where the enzyme forms a heterodimer with alpha-lactalbumin to catalyze UDP-galactose + D-glucose <=> UDP + lactose. The two enzymatic forms result from alternate transcription initiation sites and post-translational processing.
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