Search Thermo Fisher Scientific
Invitrogen
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
Recommended positive controls: A549, HeLa, HepG2, HCT116.
Predicted reactivity: Mouse (96%), Rat (95%), Rhesus Monkey (99%), Bovine (95%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: BAG family molecular chaperone regulator 2; BAG-2; BAG-family molecular chaperone regulator-2; Bcl-2-associated athanogene 2; BCL2-associated athanogene 2; dJ417I1.2 (BAG-family molecular chaperone regulator 2); KIAA0576; MGC149462; RP3-496N17.2
基因别名: BAG-2; BAG2; dJ417I1.2
UniProt ID: (Human) O95816
Entrez Gene ID: (Human) 9532
分子生物学功能:
chaperone