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产品信息
10398-1-AP
产品规格
种属反应
Human,
Mouse
已发表种属
Not Applicable
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
BAP1 Fusion Protein Ag0597 (18-228 aa encoded by BC001596)
偶联物
形式
Liquid
浓度
0.13 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: LVEDFGVKG VQVEEIYDLQ SKCQGPVYGF IFLFKWIEER RSRRKVSTLV DDTSVIDDDI VNNMFFAHQL IPNSCATHAL LSVLLNCSSV DLGPTLSRMK DFTKGFSPES KGYAIGNAPE LAKAHNSHAR PEPRHLPEKQ NGLSAVRTME AFHFVSYVPI TGRLFELDGL KVYPIDHGPW GEDEEWTDKA RRVIMERIGL ATAGEPYHDI RF (18-228 aa encoded by BC001596)
靶标信息
BRCA1-associated protein-1, or BAP1, interacts with the RING finger domain of BRCA1. The N-terminal 240 amino acids of the predicted 729-amino acid human protein show homology to ubiquitin C-terminal hydrolases (UCHs), thiol proteases that catalyze proteolytic processing of ubiquitin. In addition, BAP1 contains an acidic region, a highly charged C-terminal region, and 2 putative nuclear localization signals. BAP1 and BRCA1 associate in vivo and have overlapping subnuclear localization patterns. BAP1 enhances BRCA1-mediated inhibition of breast cancer cell growth. Northern blot analysis indicates that BAP1 is expressed as a 4-kb mRNA in all human tissues tested, with A 4. 8-kb transcript expressed exclusively in testis. Northern blot analysis and in situ hybridization reveal that BAP1 and BRCA1 are coexpressed during murine breast development and remodeling. The BAP1 gene has been mapped to 3p21. 3, a region of loss of heterozygosity for breast cancer as well as frequently deleted in lung carcinomas. Intragenic homozygous rearrangements and deletions of BAP1 appear in lung carcinoma cell lines. It has been postulated that BAP1 is a tumor suppressor gene that functions in the BRCA1 growth control pathway.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase); BRCA1-associated protein 1; Cerebral protein 6; cerebral protein-13; DKFZp686N04275; FLJ35406; FLJ37180; Ubiquitin C-terminal hydrolase X4; Ubiquitin carboxyl-terminal hydrolase BAP1; UCH-X4
基因别名: 2300006C11Rik; AA989761; AW553466; BAP1; HUCEP-13; hucep-6; KIAA0272; mKIAA0272; uch-x4; UCHL2
UniProt ID: (Human) Q92560, (Mouse) Q99PU7
Entrez Gene ID: (Human) 8314, (Mouse) 104416
regulation of cell growth
cellular protein modification process
ubiquitin-dependent protein catabolic process
negative regulation of cell proliferation
protein deubiquitination
monoubiquitinated protein deubiquitination
monoubiquitinated histone H2A deubiquitination
regulation of cell cycle
protein K48-linked deubiquitination
positive regulation of protein targeting to mitochondrion
proteolysis
chromatin modification
