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产品信息
8915-MSM4-P1
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, kappa
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
rBL10, 411
抗原
Human BCL10 recombinant protein (epitope aa122-168)
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
Protein A/G
保存液
PBS, pH 7.4, with 0.05% BSA
内含物
0.05% sodium azide
保存条件
4° C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Immunohistochemistry (PFA fixed): incubate antibody for 30 min RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.
靶标信息
BCL-10 is an N-terminal CARD (Caspase Recruitment Domain) containing protein that is involved in the adaptive immune response. It promotes apoptosis, pro-caspase-9 maturation, and activation of NF-kappa-B via NIK and IKK. BCL-10 is also an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. It is a substrate for MALT1. Mutations in the gene can lead to Immmunodeficiency 37 or Lymphoma, mucosa-associated lymphoid type.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: B-cell CLL/lymphoma 10; B-cell lymphoma/leukemia 10; Bcl-10; c-E10; CARD containing molecule enhancing NF-kB; CARD-containing apoptotic signaling protein; CARD-containing molecule enhancing NF-kappa-B; CARD-containing proapoptotic protein; CARD-like apoptotic protein; caspase-recruiting domain-containing protein; cCARMEN; CED-3/ICH-1 prodomain homologous E10-like regulator; Cellular homolog of vCARMEN; Cellular-E10; CIPER; hCLAP; Mamm; Mammalian CARD-containing adapter molecule E10; mE10; OTTHUMP00000011647; OTTHUMP00000036080; RP11-234D19.2
基因别名: BCL10; c-E10; CARMEN; CIPER; CLAP; IMD37; mE10
UniProt ID: (Human) O95999
Entrez Gene ID: (Human) 8915
protease binding
transcription coactivator activity
protein binding
protein C-terminus binding
transcription factor binding
kinase activator activity
enzyme binding
kinase binding
protein kinase binding
ubiquitin protein ligase binding
identical protein binding
ubiquitin binding
protein kinase B binding
protein self-association
NF-kappaB binding
B cell apoptotic process
neural tube closure
stimulatory C-type lectin receptor signaling pathway
toll-like receptor signaling pathway
response to molecule of bacterial origin
adaptive immune response
negative regulation of mature B cell apoptotic process
cellular defense response
I-kappaB kinase/NF-kappaB signaling
cell death
response to fungus
immunoglobulin mediated immune response
positive regulation of protein ubiquitination
response to food
positive regulation of mast cell cytokine production
Fc-epsilon receptor signaling pathway
lymphotoxin A biosynthetic process
interleukin-6 biosynthetic process
positive regulation of phosphorylation
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
innate immune response
positive regulation of interleukin-8 biosynthetic process
positive regulation of transcription, DNA-templated
T cell receptor signaling pathway
regulation of T cell receptor signaling pathway
positive regulation of T cell activation
positive regulation of NF-kappaB transcription factor activity
protein oligomerization
protein homooligomerization
protein heterooligomerization
T cell apoptotic process
cellular response to mechanical stimulus
positive regulation of extrinsic apoptotic signaling pathway
