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产品信息
26672-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Not Applicable
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
BDKRB1 Fusion Protein Ag24745 (94-154 aa encoded by BC034705)
偶联物
形式
Liquid
浓度
0.37 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: AENIWNQFN WPFGALLCRV INGVIKANLF ISIFLVVAIS QDRYRVLVHP MASRRQQRRR QA (94-154 aa encoded by BC034705)
靶标信息
Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: B1 bradykinin receptor; B1R; Bk b1 receptor; BK-1 receptor; BKRB1; bradykinin B1 receptor; bradykinin receptor 1; bradykinin receptor B2
基因别名: B1BKR; B1R; BDKRB1; BDKRB2; BKB1R; BKR1; BRADYB1
UniProt ID: (Human) P46663
Entrez Gene ID: (Human) 623
negative regulation of protein phosphorylation
positive regulation of leukocyte migration
inflammatory response
positive regulation of cytosolic calcium ion concentration
protein kinase C-activating G-protein coupled receptor signaling pathway
response to mechanical stimulus
cell migration
sensory perception of pain
negative regulation of cell growth
response to lipopolysaccharide
negative regulation of blood pressure
positive regulation of release of sequestered calcium ion into cytosol
