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产品信息
H00000623-B02P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
BDKRB1 (NP_000701.2, 1 a.a. approximately 353 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
0.5-1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MASSWPPLEL QSSNQSQLFP QNATACDNAP EAWDLLHRVL PTFIISICFF GLLGNLFVLL VFLLPRRQLN VAEIYLANLA ASDLVFVLGL PFWAENIWNQ FNWPFGALLC RVINGVIKAN LFISIFLVVA ISQDRYRVLV HPMASRRQQR RRQARVTCVL IWVVGGLLSI PTFLLRSIQA VPDLNITACI LLLPHEAWHF ARIVELNILG FLLPLAAIVF FNYHILASLR TREEVSRTRC GGRKDSKTTA LILTLVVAFL VCWAPYHFFA FLEFLFQVQA VRGCFWEDFI DLGLQLANFF AFTNSSLNPV IYVFVGRLFR TKVWELYKQC TPKSLAPISS SHRKEIFQLF WRN
靶标信息
Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: B1 bradykinin receptor; B1R; Bk b1 receptor; BK-1 receptor; BKRB1; bradykinin B1 receptor; bradykinin receptor 1; bradykinin receptor B2
基因别名: B1BKR; B1R; BDKRB1; BDKRB2; BKB1R; BKR1; BRADYB1
UniProt ID: (Human) P46663
Entrez Gene ID: (Human) 623
negative regulation of protein phosphorylation
positive regulation of leukocyte migration
inflammatory response
positive regulation of cytosolic calcium ion concentration
protein kinase C-activating G-protein coupled receptor signaling pathway
response to mechanical stimulus
cell migration
sensory perception of pain
negative regulation of cell growth
response to lipopolysaccharide
negative regulation of blood pressure
positive regulation of release of sequestered calcium ion into cytosol
