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产品信息
PA5-22845
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide made to an internal region (within residues 1-100) of the human Bmi1 protein.
偶联物
激发/发射光谱
651/673 nm
查看光谱
形式
Liquid
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
50mM sodium borate
内含物
no preservative
保存条件
4° C, store in dark
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_11154352
产品详细信息
Suggested positive control: human and mouse skeletal muscle.
靶标信息
Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: B lymphoma Mo-MLV insertion region 1; B lymphoma Mo-MLV insertion region 1 homolog; BMI1 polycomb ring finger oncogene; BMI1 polycomb ring finger proto-oncogene; murine leukemia viral (bmi-1) oncogene homolog; Pcgf4 antibody; Polycomb complex protein BMI-1; polycomb group protein Bmi1; polycomb group ring finger 4; Polycomb group RING finger protein 4; RING finger protein 51; RP11-573G6.1
基因别名: AW546694; Bmi-1; BMI1; flvi-2/bmi-1; FLVI2/BMI1; PCGF4; RNF51
UniProt ID: (Human) P35226, (Mouse) P25916
Entrez Gene ID: (Human) 648, (Mouse) 12151
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
segment specification
regulation of gene expression
covalent chromatin modification
protein sumoylation
hemopoiesis
negative regulation of gene expression, epigenetic
positive regulation of fibroblast proliferation
positive regulation of ubiquitin-protein transferase activity
skeletal system development
in utero embryonic development
DNA methylation
regulation of transcription, DNA-templated
humoral immune response
brain development
cellular process
chromatin modification
histone acetylation
histone ubiquitination
rostrocaudal neural tube patterning
positive regulation of B cell proliferation
positive regulation of immature T cell proliferation in thymus
somatic stem cell division
embryonic skeletal system morphogenesis
embryonic skeletal system development
regulation of catalytic activity
hematopoietic stem cell homeostasis
negative regulation of apoptotic signaling pathway
